Evidence map›Paper›PMID 28971229›Full record

ArticlePsychopharmacology2018

Role of the guanine nucleotide binding protein, Gα

Jennifer T Lamberts, Lisa D Rosenthal, Emily M Jutkiewicz, John R Traynor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Genetic mouse models in opioid research: current status and future directions.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  2. A Building Block Approach for the Total Synthesis of YM-385781.European journal of organic chemistry · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jennifer T LambertsDepartment of Pharmacology and Edward F. Domino Research Center, University of Michigan Medical School, 1150 W. Medical Center Dr., 1301 MSRB III, Ann Arbor, MI, 48109-5632, USA.
Lisa D RosenthalDepartment of Pharmacology and Edward F. Domino Research Center, University of Michigan Medical School, 1150 W. Medical Center Dr., 1301 MSRB III, Ann Arbor, MI, 48109-5632, USA.
Emily M JutkiewiczDepartment of Pharmacology and Edward F. Domino Research Center, University of Michigan Medical School, 1150 W. Medical Center Dr., 1301 MSRB III, Ann Arbor, MI, 48109-5632, USA.
John R TraynorDepartment of Pharmacology and Edward F. Domino Research Center, University of Michigan Medical School, 1150 W. Medical Center Dr., 1301 MSRB III, Ann Arbor, MI, 48109-5632, USA. jtraynor@umich.edu.

Funding

INTERDEPARTMENTAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007767 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 1985 to 2019
$10.2M
SUBSTANCE ABUSE INTERDISCIPLINARY TRAINING PROGRAMT32DA007267 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GNEGY, MARGARET E · 1994 to 2015
$4.5M
Regulator of G protein signaling proteins differentially control opioid analgesiaR01DA035316 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 2014 to 2018
$2.7M
NIDA NIH HHS DA 035316NIDA NIH HHS R01 DA035316NIDA NIH HHS T32 DA007267NIGMS NIH HHS GM 007767NIGMS NIH HHS T32 GM007767
6 · The paper itself

Abstract

rationaleThe use of morphine and other opioids for chronic pain is limited by the development of analgesic tolerance and physical dependence. Morphine produces its effects by activating the μ opioid receptor, which couples to Gα

objectiveThe objective of the study is to evaluate the contribution of Gα

methods129S6 mice lacking one copy of the Gα

resultsFollowing either acute or chronic morphine treatment, all mice developed antinociceptive tolerance and physical dependence, regardless of genotype. With chronic morphine treatment, Gα

conclusionsThese data suggest that the guanine nucleotide binding protein Gα

Indexed as

Analgesics, OpioidAnimalsDrug ToleranceGTP-Binding Protein alpha Subunits, Gi-GoMiceMice, KnockoutMorphineMorphine DependenceNaltrexoneNarcotic AntagonistsNarcoticsNociceptionPain MeasurementReceptors, Opioid, muSubstance Withdrawal SyndromeAnalgesics, OpioidGNAO1 protein, mouseGTP-Binding Protein alpha Subunits, Gi-GoMorphineNaltrexoneNarcotic AntagonistsNarcoticsOprm protein, mouseReceptors, Opioid, muAntinociceptionG proteinMorphineReceptor bindingToleranceWithdrawalμ receptor

Identifiers

PMID28971229
PMCPMC5819733

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.