ArticlePsychopharmacology2017
Cortical thickness and trait empathy in patients and people at high risk for alcohol use disorders.
Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Systematic review and meta-analysis on the association between theory of mind and alcohol problems in non-clinical samples.Alcoholism, clinical and experimental research · 2022Pooled it
- Meta-analysis of associations between empathy and alcohol use and problems in clinical and non-clinical samples.Addiction (Abingdon, England) · 2022Pooled it
- Anxiety during abstinence from alcohol: A systematic review of rodent and human evidence for the anterior insula's role in the abstinence network.Addiction biology · 2021Pooled it
- Predicting the degree of trait emotional empathy from cortical features using surface-based morphometry.Scientific reports · 2026Article
- Adolescent empathy predicts reduced neural responses to social rejection in adulthood.Development and psychopathology · 2026Article
- Childhood abuse and neglect are differentially related to perceived discrimination and structural change in empathy-related circuitry.Scientific reports · 2025Article
- Neuroanatomical correlates of aggressiveness: a case-control voxel- and surface-based morphometric study.Brain structure & function · 2024Article
- Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.Molecular psychiatry · 2023Article
- Association Between Brain Structure and Alcohol Use Behaviors in Adults: A Mendelian Randomization and Multiomics Study.JAMA psychiatry · 2022Article
- Association between empathy and drinking among a community sample of heavy drinkers: Sex differences and neural correlates.Addictive behaviors · 2022Article
- Probing the role of the right inferior frontal gyrus during Pain-Related empathy processing: Evidence from fMRI and TMS.Human brain mapping · 2021Article
- Emotional processing and social cognition in alcohol use disorder.Neuropsychology · 2019Review
- Neuroanatomical and Functional Correlates of Cognitive and Affective Empathy in Young Healthy Adults.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleAlcoholism not only affects individuals with alcohol use disorder (AUD) but also their biological relatives. This high-risk (HR) group has a higher probability to develop AUD. The aim of our study was to compare cortical thickness (CT) in AUD patients relative to participants with (HR) and without (non-HR) familial predisposition for AUD. We focused on empathy-related brain areas as sociocognitive impairment represents a known risk factor for AUD.
methodWe examined 13 individuals with AUD, 14 HR individuals, and 20 non-HR participants using high-resolution T1-weighted magnetic resonance images (3 Tesla) to investigate differences in CT. CT was correlated with self-reported empathy in empathy-related areas.
resultsAUD patients showed decreased CT in the left inferior and superior frontal gyri, the right precuneus and bilaterally in the middle frontal gyri/the insula relative to the HR group, and in the left insula, the right middle frontal gyrus and bilaterally in the superior frontal gyrus/the precuneus relative to the non-HR group (all ps < 0.036, all ƞ
conclusionsWe present preliminary evidence of CT reduction in empathy-associated brain regions in patients with AUD relative to healthy participants with and without familial predisposition for AUD. The results have to be interpreted with caution due to low sample sizes and potential confounding effects of medication, gender, and withdrawal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.