ArticleHeliyon2017
Significant correlation between openness personality in normal subjects and brain myelin mapping with T1/T2-weighted MR imaging.
Article in Heliyon, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Neurocircuitry of Personality Traits and Intent in Decision-Making.Behavioral sciences (Basel, Switzerland) · 2023Review
- Cortical gray-white matter contrast abnormalities in male children with attention deficit hyperactivity disorder.Frontiers in human neuroscience · 2023Article
- The neurobiology of openness as a personality trait.Frontiers in neurology · 2023Review
- The interindividual variability of multimodal brain connectivity maintains spatial heterogeneity and relates to tissue microstructure.Communications biology · 2022Article
- T1w/T2w Ratio and Cognition in 9-to-11-Year-Old Children.Brain sciences · 2022Article
- "Nothing to see here": No structural brain differences as a function of thePersonality neuroscience · 2022Review
- A Neuroimaging Study of Personality Traits and Self-Reflection.Behavioral sciences (Basel, Switzerland) · 2019Article
- Intra-cortical myelin mediates personality differences.Journal of personality · 2019Article
- Altered Intracortical TFrontiers in neuroscience · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to examine the relationship between the myelination and the psychological trait of openness to experience in young cognitively normal volunteers using regional T1-weighted (T1w)/T2w ratios on magnetic resonance imaging (MRI). It was hypothesized that axonal myelination would be related to openness, thus linking trait creativity and mental illness.
methodsWe recruited 37 healthy subjects and administered the NEO Five-Factor Inventory to assess personality factors. Regional T1w/T2w MRI values were computed as surrogate indicators of myelination status and correlations between T1w/T2w values and various personality factors (e.g., trait of openness) were calculated with a voxel-based analysis using statistical parametric mapping.
resultsSignificant negative correlations were identified between the trait of openness and T1w/T2w values in the medial frontal cortex, anterior cingulate cortex, posterior cingulate cortex, and posterior insula/adjacent putamen. These relationships remained significant even after adjusting for age, sex, and education as covariates. There were no significant correlations between other personality factors and regional volumes.
conclusionsIndividual differences in openness may be associated with variations in intra-cortical myelination, specifically in the imaginative network of the brain including the midline core 'hubs' of the default mode network (anterior cingulate/medial frontal cortex and posterior cingulate cortex) and regions related to motivational state (posterior insula and adjacent putamen). Signal interference related to decreased myelination may facilitate flexible imagination and the trait of openness. Our findings assist in understanding the relationship between myelination and openness, as a link between creativity and mental illness.
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