Evidence map›Paper›PMID 28971147›Full record

ArticleHeliyon2017

Statins decrease vascular epithelial growth factor expression via down-regulation of receptor for advanced glycation end-products.

Hiroki Tsujinaka, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Ryogo Shobatake, Mai Makino, Naonori Masuda, Hiromasa Hirai, Shin Takasawa, Nahoko Ogata

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hiroki TsujinakaDepartment of Ophthalmology, Nara Medical University, Kashihara 634-8522, Japan.
Asako Itaya-HironakaDepartment of Biochemistry, Nara Medical University, Kashihara 634-8521, Japan.
Akiyo YamauchiDepartment of Biochemistry, Nara Medical University, Kashihara 634-8521, Japan.
Sumiyo Sakuramoto-TsuchidaDepartment of Biochemistry, Nara Medical University, Kashihara 634-8521, Japan.
Ryogo ShobatakeDepartment of Biochemistry, Nara Medical University, Kashihara 634-8521, Japan.
Mai MakinoDepartment of Biochemistry, Nara Medical University, Kashihara 634-8521, Japan.
Naonori MasudaDepartment of Ophthalmology, Nara Medical University, Kashihara 634-8522, Japan.
Hiromasa HiraiDepartment of Ophthalmology, Nara Medical University, Kashihara 634-8522, Japan.
Shin TakasawaDepartment of Biochemistry, Nara Medical University, Kashihara 634-8521, Japan.
Nahoko OgataDepartment of Ophthalmology, Nara Medical University, Kashihara 634-8522, Japan.
Nara Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsStatins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, possess pleiotropic effects that have been extended to modulation of various cellular behaviors. This study aimed to examine whether statins modulate vascular endothelial growth factor A ( MAIN

methodsHuman RPE cells (h1RPE7), damaged by hydroquinone (HQ) + advanced glycation endproducts (AGE) in an KEY

findingsThe mRNA levels of SIGNIFICANCE: Statins attenuated HQ + AGE-induced VEGF expression by decreasing RAGE expression. As VEGF is an important factor in developing wet AMD, statins could decrease the risk of wet-type AMD and be used as preventive medicines.

Indexed as

BiochemistryBiological sciencesCell biologyOphthalmology

Identifiers

PMID28971147
PMCPMC5612812
OpenAlexW2758339763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.