Evidence map›Paper›PMID 28971142›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2017

Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry.

Daniel J Tward, Chelsea S Sicat, Timothy Brown, Arnold Bakker, Michela Gallagher, Marilyn Albert, Michael Miller

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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  6. 14-3-3Journal of neuroinflammation · 2023
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  9. LESA: Longitudinal Elastic Shape Analysis of Brain Subcortical Structures.Journal of the American Statistical Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel J TwardCenter for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.
Chelsea S SicatCenter for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.
Timothy BrownCenter for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.
Arnold BakkerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Michela GallagherDepartment of Psychological and Brain Sciences, Johns Hopkins School of Arts and Sciences, Baltimore, MD, USA.
Marilyn AlbertDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael MillerCenter for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Biomarkers of Cognitive Decline among Normal Individuals: The BIOCARD cohortU01AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 2009 to 2013
$11.2M
PHASE II/III trial for Slowing Progression in Mild Cognitive ImpairmentR01AG048349 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S., GALLAGHER, MICHELA · 2015 to 2021
$7.6M
NIA NIH HHS P50 AG005146NIA NIH HHS R01 AG048349NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG033655NIBIB NIH HHS P41 EB015909
6 · The paper itself

Abstract

introductionAutopsy findings have shown the entorhinal cortex and transentorhinal cortex are among the earliest sites of accumulation of pathology in patients developing Alzheimer's disease.

methodsHere, we study this region in subjects with mild cognitive impairment (

resultsWe find significant thickness and volume changes localized to the transentorhinal cortex through high field strength atlasing. DISCUSSION: This demonstrates that in vivo neuroimaging biomarkers can detect these early changes among subjects with mild cognitive impairment.

Indexed as

Braak stagingDiffeomorphometryEntorhinal cortexLongitudinal analysisMild cognitive impairmentShape analysis

Identifiers

PMID28971142
PMCPMC5608074

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.