Evidence map›Paper›PMID 28971106›Full record

ReviewGlobal cardiology science & practice2017

Mechanistic targets for the ablation of atrial fibrillation.

Junaid A B Zaman, Tina Baykaner, Amir A Schricker, David E Krummen, Sanjiv M Narayan

Abstract readReview
In one paragraph

Review in Global cardiology science & practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Mapping and Imaging in Non-paroxysmal AF.Arrhythmia & electrophysiology review · 2019
    Review
  4. Source Determination in Atrial Fibrillation.Arrhythmia & electrophysiology review · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Junaid A B ZamanStanford University, Palo Alto, California.
Tina BaykanerStanford University, Palo Alto, California.
Amir A SchrickerUniversity of California, San Diego, California.
David E KrummenUniversity of California, San Diego, California.
Sanjiv M NarayanStanford University, Palo Alto, California.

Funding

British Heart Foundation FS/14/46/30907
6 · The paper itself

Abstract

The mechanisms responsible for sustaining atrial fibrillation are a key debate in cardiovascular pathophysiology, and directly influence the approach to therapy including ablation Clinical and basic studies have split AF mechanisms into two basic camps: 'spatially distributed disorganization' and 'localized sources'. Recent data suggest that these mechanisms can also be separated by the method for mapping - with nearly all traditional electrogram analyses showing spatially distributed disorganization and nearly all optical mapping studies showing localized sources We will review this dichotomy in light of these recently identified differences in mapping, and in the context of recent clinical studies in which localized ablation has been shown to impact AF, also lending support to the localized source hypothesis. We will conclude with other concepts on mechanism-based ablation and areas of ongoing research that must be addressed to continue improving our knowledge and treatment of AF.

Identifiers

PMID28971106
PMCPMC5621726

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.