ArticleNeuroImage. Clinical2017
Neuromagnetic responses to tactile stimulation of the fingers: Evidence for reduced cortical inhibition for children with Autism Spectrum Disorder and children with epilepsy.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Review
- Noninvasive Biomarkers for Assessing the Excitatory/Inhibitory Imbalance in Children with Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Article
- EEG-based functional connectivity for tactile roughness discrimination.Cognitive neurodynamics · 2023Article
- Visual Evoked Potential Abnormalities in Phelan-McDermid Syndrome.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Article
- A Multidimensional Investigation of Sensory Processing in Autism: Parent- and Self-Report Questionnaires, Psychophysical Thresholds, and Event-Related Potentials in the Auditory and Somatosensory Modalities.Frontiers in human neuroscience · 2022Article
- Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum.Molecular autism · 2021Article
- Body maps in the infant brain: implications for neurodevelopmental disabilities.Developmental medicine and child neurology · 2020Review
- Vibration Alert to the Brain: Evoked and Induced MEG Responses to High-Frequency Vibrotactile Stimuli on the Index Finger of Dominant and Non-dominant Hand.Frontiers in human neuroscience · 2020Article
- Importance of body representations in social-cognitive development: New insights from infant brain science.Progress in brain research · 2020Review
- The Potential of Repetitive Transcranial Magnetic Stimulation for Autism Spectrum Disorder: A Consensus Statement.Biological psychiatry · 2019Article
- Massive cortical reorganization is reversible following bilateral transplants of the hands: evidence from the first successful bilateral pediatric hand transplant patient.Annals of clinical and translational neurology · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The purpose of this study was to compare somatosensory responses from a group of children with epilepsy and a group of children with autism spectrum disorder (ASD), with age matched TD controls. We hypothesized that the magnitude of the tactile "P50m" somatosensory response would be reduced in both patient groups, possibly due to reduced GABAergic signaling as has been implicated in a variety of previous animal models and in vivo human MRS studies. We observed significant (~ 25%) decreases in tactile P50m dipole moment values from the source localized tactile P50m response, both for children with epilepsy and for children with ASD. In addition, the latency of the tactile P50m peak was observed to be equivalent between TD and ASD groups but was significantly delayed in children with epilepsy by ~ 6 ms. Our data support the hypothesis of impaired GABAergic signaling in both children with ASD and children with epilepsy. Further work is needed to replicate these findings and directly relate them to both in vivo measures of GABA via e.g. magnetic resonance spectroscopy and psychophysical assessments of somatosensory function, and behavioral indices.
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Registered trials
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