Evidence map›Paper›PMID 28971006›Full record

ArticleNeuroImage. Clinical2017

Dysfunctional gaze processing in bipolar disorder.

Cristina Berchio, Camille Piguet, Christoph M Michel, Paolo Cordera, Tonia A Rihs, Alexandre G Dayer, Jean-Michel Aubry

Abstract read
In one paragraph

Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cristina BerchioDepartment of Basic Neurosciences, University of Geneva, Geneva, Switzerland.
Camille PiguetDepartment of Basic Neurosciences, University of Geneva, Geneva, Switzerland.
Christoph M MichelDepartment of Basic Neurosciences, University of Geneva, Geneva, Switzerland.
Paolo CorderaDepartment of Mental Health and Psychiatry, Service of Psychiatric Specialties, Mood Disorders Unit University Hospitals of Geneva, Switzerland.
Tonia A RihsDepartment of Basic Neurosciences, University of Geneva, Geneva, Switzerland.
Alexandre G DayerDepartment of Basic Neurosciences, University of Geneva, Geneva, Switzerland.
Jean-Michel AubryDepartment of Mental Health and Psychiatry, Service of Psychiatric Specialties, Mood Disorders Unit University Hospitals of Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gaze conveys emotional information, and humans present sensitivity to its direction from the earliest days of life. Bipolar disorder is a disease characterized by fluctuating states of emotional and cognitive dysregulation. To explore the role of attentional control on face processing in bipolar patients (BP) we used gaze direction as an emotion modulation parameter in a two-back Working Memory (WM) task while high-density EEG data were acquired. Since gaze direction influences emotional attributions to faces with neutral expressions as well, we presented neutral faces with direct and averted gaze. Nineteen euthymic BP and a sample of age- and gender-matched controls were examined. In BP we observed diminished P200 and augmented P300 evoked responses, differentially modulated by non-repeated or repeated faces, as well as by gaze direction. BP showed a reduced P200 amplitude, significantly stronger for faces with direct gaze than averted gaze. Source localization of P200 indicated decreased activity in sensory-motor regions and frontal areas suggestive of abnormal affective processing of neutral faces. The present study provides neurophysiological evidence for abnormal gaze processing in BP and suggests dysfunctional processing of direct eye contact as a prominent characteristic of bipolar disorder.

Indexed as

AdultAttentionBipolar DisorderBrainElectroencephalographyEmotionsEvoked Potentials, VisualFacial ExpressionFemaleFixation, OcularHumansMaleMiddle AgedVisual PerceptionBipolar disorderEEG source imagingERPFace recognitionGaze processingMemory

Identifiers

PMID28971006
PMCPMC5608173

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.