ArticleChemical science2017
Single-molecule spectroelectrochemical cross-correlation during redox cycling in recessed dual ring electrode zero-mode waveguides.
Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Metabolic and Oxidative Stress Effects on the Spectroelectrochemical Behavior of SingleChemical & biomedical imaging · 2023Article
- Strategies for Overcoming the Single-Molecule Concentration Barrier.ACS measurement science au · 2023Review
- Spectroelectrochemical behavior of parallel arrays of single vertically oriented Pseudomonas aeruginosa cells.Cell reports. Physical science · 2023Article
- Potential Dependent Spectroelectrochemistry of Electrofluorogenic Dyes on Indium-Tin Oxide.Electrochemical science advances · 2022Article
- Gold Ion Beam Milled Gold Zero-Mode Waveguides.Nanomaterials (Basel, Switzerland) · 2022Article
- Electrochemical Zero-Mode Waveguide Potential-Dependent Fluorescence of Glutathione Reductase at Single-Molecule Occupancy.Analytical chemistry · 2022Article
- Rapid Identification of DNA Fragments through Direct Sequencing with Electro-Optical Zero-Mode Waveguides.Advanced materials (Deerfield Beach, Fla.) · 2022Article
- Acid-base chemistry at the single ion limit.Chemical science · 2020Article
- Nanoelectrochemistry in the study of single-cell signaling.Analytical and bioanalytical chemistry · 2020Review
- Single Entity Electrochemistry in Nanopore Electrode Arrays: Ion Transport Meets Electron Transfer in Confined Geometries.Accounts of chemical research · 2020Article
- Detection of Protein Toxin Simulants from Contaminated Surfaces by Paper Spray Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2019Article
- Capture of Single Silver Nanoparticles in Nanopore Arrays Detected by Simultaneous Amperometry and Surface-Enhanced Raman Scattering.Analytical chemistry · 2019Article
- Nanopore-Templated Silver Nanoparticle Arrays Photopolymerized in Zero-Mode Waveguides.Frontiers in chemistry · 2019Article
- Enhanced annihilation electrochemiluminescence by nanofluidic confinement.Chemical science · 2018Article
- Electrochemical Zero-Mode Waveguide Studies of Single Enzyme Reactions.Proceedings of the ... IEEE Conference on Nanotechnology. IEEE Conference on Nanotechnology · 2018Article
- Zero-Mode Waveguide Nanophotonic Structures for Single Molecule Characterization.Journal of physics D: Applied physics · 2018Article
- Voltage-Gated Nanoparticle Transport and Collisions in Attoliter-Volume Nanopore Electrode Arrays.Small (Weinheim an der Bergstrasse, Germany) · 2018Article
- Nanopore Electrochemistry: A Nexus for Molecular Control of Electron Transfer Reactions.ACS central science · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of zero-mode waveguides (ZMW) to guide light into subwavelength-diameter nanoapertures has been exploited for studying electron transfer dynamics in zeptoliter-volume nanopores under single-molecule occupancy conditions. In this work, we report the spectroelectrochemical detection of individual molecules of the redox-active, fluorogenic molecule flavin mononucleotide (FMN) freely diffusing in solution. Our approach is based on an array of nanopore-confined recessed dual ring electrodes, wherein repeated reduction and oxidation of a single molecule at two closely spaced annular working electrodes yields amplified electrochemical signals. We have articulated these structures with an optically transparent bottom, so that the nanopores are bifunctional, exhibiting both nanophotonic and nanoelectrochemical behaviors allowing the coupling between electron transfer and fluorescence dynamics to be studied under redox cycling conditions. We also investigated the electric field intensity in electrochemical ZMWs (E-ZMW) through finite-element simulations, and the amplification of fluorescence by redox cycling agrees well with predictions based on optical confinement effects inside the E-ZMW. Proof-of-principle experiments are conducted showing that electrochemical and fluorescence signals may be correlated to reveal single molecule fluctuations in the array population. Cross-correlation of single molecule fluctuations in amperometric response and single photon emission provides unequivocal evidence of single molecule sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.