ArticleChemical science2017
Characterization of the flavoenzyme XiaK as an
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Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
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- Diverse N-Oxidation of Primary Aromatic Amines Controlled by Engineered P450 Peroxizyme Variants Facilitated by Dual-Functional Small Molecule.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Highly chemoselective oxidative dimerization of indolosesquiterpene alkaloids: a biomimetic approach to dixiamycin.Chemical science · 2024Article
- Unlocking the potential of bacterial endophytes from medicinal plants for drug discovery.Microbial biotechnology · 2024Review
- Total synthesis of atropisomeric indolosesquiterpenoidsChemical science · 2023Article
- Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation.Nature communications · 2022Article
- Flavin-enabled reductive and oxidative epoxide ring opening reactions.Nature communications · 2022Article
- Cryptic halogenation reactions in natural product biosynthesis.Natural product reports · 2021Review
- Biosynthesis of sulfonamide and sulfamate antibiotics in actinomycete.Journal of industrial microbiology & biotechnology · 2021Review
- Induced Production, Synthesis, and Immunomodulatory Action of Clostrisulfone, a Diarylsulfone from Clostridium acetobutylicum.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Flavin-dependent N-hydroxylating enzymes: distribution and application.Applied microbiology and biotechnology · 2020Review
- Nitric oxide as a source for bacterial triazole biosynthesis.Nature communications · 2020Article
- Total Syntheses of Xiamycins A, C, F, H and Oridamycin A and Preliminary Evaluation of their Anti-Fungal Properties.Angewandte Chemie (International ed. in English) · 2019Article
- Molecular mechanism of azoxy bond formation for azoxymycins biosynthesis.Nature communications · 2019Article
- Characterization of Two Toxin-Antitoxin Systems in Deep-SeaMarine drugs · 2019Article
- Efficient biosynthesis of heterodimeric CNature communications · 2018Article
- Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines.Nature communications · 2018Article
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Authors and funding
13 authors at 6 institutions in 4 countries.
Qingbo ZhangCAS Key Laboratory of Tropical Marine Bio-resources and Ecology , Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology , Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou 510301 , China . Email: czhang2006@gmail.com ; Email: czhang@scsio.ac.cn.
Huixian LiCAS Key Laboratory of Tropical Marine Bio-resources and Ecology , Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology , Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou 510301 , China . Email: czhang2006@gmail.com ; Email: czhang@scsio.ac.cn.
Lu YuHefei National Laboratory of Microscale Physical Sciences , School of Life Science , University of Science and Technology of China , Hefei , 230027 , China.
Yu SunState Key Laboratory of Bioorganic and Natural Products Chemistry , Shanghai Institute of Organic Chemistry , Chinese Academy of Sciences , 345 Lingling Road , Shanghai 200032 , China.
Yiguang ZhuCAS Key Laboratory of Tropical Marine Bio-resources and Ecology , Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology , Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou 510301 , China . Email: czhang2006@gmail.com ; Email: czhang@scsio.ac.cn.
Hanning ZhuCAS Key Laboratory of Tropical Marine Bio-resources and Ecology , Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology , Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou 510301 , China . Email: czhang2006@gmail.com ; Email: czhang@scsio.ac.cn.
Liping ZhangCAS Key Laboratory of Tropical Marine Bio-resources and Ecology , Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology , Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou 510301 , China . Email: czhang2006@gmail.com ; Email: czhang@scsio.ac.cn.
Shu-Ming LiInstitut für Pharmazeutische Biologie und Biotechnologie , Philipps-Universität Marburg , Deutschhausstrasse 17a , 35037 Marburg , Germany.
Yuemao ShenState Key Laboratory of Microbial Technology , School of Life Science , Shandong University , Jinan 250100 , China.ORCID 0000-0002-3881-0135
Changlin TianHefei National Laboratory of Microscale Physical Sciences , School of Life Science , University of Science and Technology of China , Hefei , 230027 , China.ORCID 0000-0001-9315-900X
Ang LiState Key Laboratory of Bioorganic and Natural Products Chemistry , Shanghai Institute of Organic Chemistry , Chinese Academy of Sciences , 345 Lingling Road , Shanghai 200032 , China.
Hung-Wen LiuDivision of Chemical Biology and Medicinal Chemistry , College of Pharmacy , Department of Chemistry , University of Texas at Austin , Austin , TX 78712 , USA . Email: h.w.liu@mail.utexas.edu.
Changsheng ZhangCAS Key Laboratory of Tropical Marine Bio-resources and Ecology , Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology , Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou 510301 , China . Email: czhang2006@gmail.com ; Email: czhang@scsio.ac.cn.ORCID 0000-0003-2349-3138
Chinese Academy of Sciences · CNUniversity of Science and Technology of China · CNInstitute of Medicinal Plant Development · CNPhilipps University of Marburg · DEShandong University · CNSun Yat-sen University · CN
Funding
Three-Membered Ring Metabolites, Inhibition &FormationR01GM040541 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI LIU, HUNG-WEN · 1989 to 2023
$7.4MNIGMS NIH HHS R01 GM040541
Abstract
Flavoenzymes are ubiquitous in biological systems and catalyze a diverse range of chemical transformations. The flavoenzyme XiaK from the biosynthetic pathway of the indolosesquiterpene xiamycin A is demonstrated to mediate the
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