Evidence map›Paper›PMID 28970824›Full record

ArticleFrontiers in microbiology2017

Identification of Novel Serodiagnostic Signatures of Typhoid Fever Using a

Thomas C Darton, Stephen Baker, Arlo Randall, Sabina Dongol, Abhilasha Karkey, Merryn Voysey, Michael J Carter, Claire Jones, Krista Trappl, Jozelyn Pablo and 11 more

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01405521 (Understanding Typhoid Disease After Vaccination), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01405521 phase2completednot on this map

Understanding Typhoid Disease After Vaccination: a Single Centre, Randomised, Doubleblind, Placebo Controlled Study to Evaluate M01ZH09 in a Healthy Adult Challenge Model, Using Ty21a Vaccine as a Positive Control.

TypeinterventionalSponsorUniversity of OxfordRan2011 to 2022Enrolled99ConditionsTyphoid Fever, Enteric Fever, TyphoidArmsVaccine placebo (excipients only), Ty21a, M10ZH09 vaccine
3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Immunoproteomics: The Evolution from Classical Methods to Emerging Techniques.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Typhoid fever.Nature reviews. Disease primers · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Typhoid and Enteric Fevers in Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021
    Article
  12. Review
  13. Antibiotic Use Prior to Hospital Presentation Among Individuals With Suspected Enteric Fever in Nepal, Bangladesh, and Pakistan.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  14. The Current Status of Enteric Fever Diagnostics and Implications for Disease Control.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  15. Typhoid Conjugate Vaccines and Enteric Fever Control: Where to Next?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  16. Article
  17. Article
  18. Plasma Immunoglobulin A Responses Against 2 Salmonella Typhi Antigens Identify Patients With Typhoid Fever.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Thomas C DartonOxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Paediatrics, and the Oxford National Institutes for Health Research Biomedical Research Centre, University of OxfordOxford, United Kingdom.
Stephen BakerThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research UnitHo Chi Minh City, Vietnam.
Arlo RandallAntigen Discovery Incorporated, IrvineCA, United States.
Sabina DongolOxford University Clinical Research Unit, Patan Academy of Health SciencesKathmandu, Nepal.
Abhilasha KarkeyOxford University Clinical Research Unit, Patan Academy of Health SciencesKathmandu, Nepal.
Merryn VoyseyOxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Paediatrics, and the Oxford National Institutes for Health Research Biomedical Research Centre, University of OxfordOxford, United Kingdom.
Michael J CarterOxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Paediatrics, and the Oxford National Institutes for Health Research Biomedical Research Centre, University of OxfordOxford, United Kingdom.
Claire JonesOxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Paediatrics, and the Oxford National Institutes for Health Research Biomedical Research Centre, University of OxfordOxford, United Kingdom.
Krista TrapplAntigen Discovery Incorporated, IrvineCA, United States.
Jozelyn PabloAntigen Discovery Incorporated, IrvineCA, United States.
Chris HungAntigen Discovery Incorporated, IrvineCA, United States.
Andy TengAntigen Discovery Incorporated, IrvineCA, United States.
Adam ShandlingAntigen Discovery Incorporated, IrvineCA, United States.
Tim LeAntigen Discovery Incorporated, IrvineCA, United States.
Cassidy WalkerAntigen Discovery Incorporated, IrvineCA, United States.
Douglas MolinaAntigen Discovery Incorporated, IrvineCA, United States.
Jason AndrewsDivision of Infectious Diseases and Geographic Medicine, Stanford University, StanfordCA, United States.
Amit ArjyalNuffield Department of Primary Care Health Sciences, University of OxfordOxford, United Kingdom.
Buddha BasnyatNuffield Department of Primary Care Health Sciences, University of OxfordOxford, United Kingdom.
Andrew J PollardOxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Paediatrics, and the Oxford National Institutes for Health Research Biomedical Research Centre, University of OxfordOxford, United Kingdom.
Christoph J BlohmkeOxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Paediatrics, and the Oxford National Institutes for Health Research Biomedical Research Centre, University of OxfordOxford, United Kingdom.

Funding

Wellcome Trust 092661
6 · The paper itself

Abstract

Current diagnostic tests for typhoid fever, the disease caused by

Indexed as

antibody responsecontrolled human infection modelenteric feverfever diagnosticsmachine learningrapid diagnostic testsSalmonella Typhiserodiagnostics

Identifiers

PMID28970824
PMCPMC5609549

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.