Evidence map›Paper›PMID 28970821›Full record

ArticleFrontiers in microbiology2017

HPV8-E6 Interferes with Syntenin-2 Expression through Deregulation of Differentiation, Methylation and Phosphatidylinositide-Kinase Dependent Mechanisms.

Benjamin Marx, Daliborka Miller-Lazic, John Doorbar, Slawomir Majewski, Kay Hofmann, Martin Hufbauer, Baki Akgül

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Benjamin MarxInstitute of Virology, University of CologneCologne, Germany.
Daliborka Miller-LazicInstitute of Virology, University of CologneCologne, Germany.
John DoorbarDepartment of Pathology, University of CambridgeCambridge, United Kingdom.
Slawomir MajewskiDepartment of Dermatology and Venereology, Medical University of WarsawWarsaw, Poland.
Kay HofmannInstitute for Genetics, University of CologneCologne, Germany.
Martin HufbauerInstitute of Virology, University of CologneCologne, Germany.
Baki AkgülInstitute of Virology, University of CologneCologne, Germany.
University of Cologne · DEMedical University of Warsaw · PLUniversity of Cambridge · GB

Funding

Medical Research Council MC_PC_13050
6 · The paper itself

Abstract

The E6 oncoproteins of high-risk human papillomaviruses (HPV) of genus alpha contain a short peptide sequence at the carboxy-terminus, the PDZ binding domain, with which they interact with the corresponding PDZ domain of cellular proteins. Interestingly, E6 proteins from papillomaviruses of genus beta (betaPV) do not encode a comparable PDZ binding domain. Irrespective of this fact, we previously showed that the E6 protein of HPV8 (betaPV type) could circumvent this deficit by targeting the PDZ protein Syntenin-2 through transcriptional repression (Lazic et al., 2012). Despite its high binding affinity to phosphatidylinositol-4,5-bisphosphate (PI(4,5)P

Indexed as

5-bisphosphatedifferentiationE6 oncoproteinhuman papillomavirus (HPV)methylationphosphatidylinositol-4Syntenin-2

Identifiers

PMID28970821
PMCPMC5609557
OpenAlexW2752214713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.