Evidence map›Paper›PMID 28970731›Full record

ArticleWorld journal of gastroenterology2017

Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the

Masaya Iwamuro, Ryuta Takenaka, Masahiro Nakagawa, Yuki Moritou, Shunsuke Saito, Shinichiro Hori, Tomoki Inaba, Yoshinari Kawai, Tatsuya Toyokawa, Takehiro Tanaka and 2 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Masaya IwamuroDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan. pr145h2k@okayama-u.ac.jp.
Ryuta TakenakaDepartment of Internal Medicine, Tsuyama Chuo Hospital, Tsuyama 7080841, Japan.
Masahiro NakagawaDepartment of Internal Medicine, Hiroshima City Hospital, Hiroshima 730-8518, Japan.
Yuki MoritouDepartment of Gastroenterology, Mitoyo General Hospital, Kanonji 7691695, Japan.
Shunsuke SaitoDepartment of Internal Medicine, Okayama Saiseikai General Hospital, Okayama 7008511, Japan.
Shinichiro HoriDepartment of Gastroenterology, Shikoku Cancer Center, Matsuyama 791-0280, Japan.
Tomoki InabaDepartment of Gastroenterology, Kagawa Prefectural Central Hospital, Takamatsu 7608557, Japan.
Yoshinari KawaiDepartment of Gastroenterology, Onomichi Municipal Hospital, Onomichi 7228503, Japan.
Tatsuya ToyokawaDepartment of Gastroenterology, Fukuyama Medical Center, Fukuyama 7208520, Japan.
Takehiro TanakaDepartment of Pathology, Okayama University Hospital, Okayama 700-8558, Japan.
Tadashi YoshinoDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Hiroyuki OkadaDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Okayama University · JPHiroshima Prefectural Hospital · JPKagawa Prefectural Central Hospital · JPOkayama Saiseikai General Hospital · JPOkayama University Hospital · JPOnomichi General Hospital · JPTsuyama Chuo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo identify the clinical features of gastric mucosa-associated lymphoid tissue (MALT) lymphoma with extra copies of MALT1.

methodsThis is a multi-centered, retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1 (Group A, n = 88), patients with t(11;18) translocation (Group B, n = 27), and patients with extra copies of MALT1 (Group C, n = 31). The clinical background, treatment, and outcomes of each group were investigated.

resultsGroups A and C showed slight female predominance, whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A (69.3%), 22 in Group B (81.5%), and 21 in Group C (67.7%). Helicobacter pylori (H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B, 14 patients underwent radiotherapy alone, which resulted in lymphoma disappearance. Although the difference was not statistically significant, event-free survival in Group C tended to be inferior to that in Group A (P = 0.10).

conclusionPatients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication, similar to patients without t(11;18) translocation or extra copies of MALT1.

Indexed as

AgedAneuploidyAnti-Bacterial AgentsAntineoplastic AgentsChromosomes, Human, Pair 11Chromosomes, Human, Pair 18Disease-Free SurvivalFemaleGastric MucosaHelicobacter InfectionsHelicobacter pyloriHumansIn Situ Hybridization, FluorescenceLymphoma, B-Cell, Marginal ZoneMaleMiddle AgedAnti-Bacterial AgentsAntineoplastic AgentsAPI2-MALT1 fusion protein, humanMALT1 protein, humanMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinOncogene Proteins, Fusion18) translocationEsophagogastroduodenoscopyExtranodal marginal zone lymphoma of mucosa-associated lymphoid tissueGastric neoplasmst(11Trisomy 18

Identifiers

PMID28970731
PMCPMC5597507
OpenAlexW2755880638

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.