Evidence map›Paper›PMID 28970722›Full record

ArticleWorld journal of gastroenterology2017

Pharmacological evaluation of NSAID-induced gastropathy as a "Translatable" model of referred visceral hypersensitivity.

Michele Hummel, Terri Knappenberger, Meghan Reilly, Garth T Whiteside

Open access · hybridAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Michele HummelPurdue Pharma L.P., Discovery Research, Cranbury, NJ 08512, United States. mhummel@trevena.com.
Terri KnappenbergerPurdue Pharma L.P., Discovery Research, Cranbury, NJ 08512, United States.
Meghan ReillyPurdue Pharma L.P., Discovery Research, Cranbury, NJ 08512, United States.
Garth T WhitesidePurdue Pharma L.P., Discovery Research, Cranbury, NJ 08512, United States.
Purdue Pharma (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate whether non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastropathy is a clinically predictive model of referred visceral hypersensitivity.

methodsGastric ulcer pain was induced by the oral administration of indomethacin to male, CD1 mice (

resultsResults showed that two opioids and a GC-C agonist, morphine, asimadoline and linaclotide, respectively, the TRP antagonists, AMG9810 and HC-030031 and the sodium channel blocker, carbamazepine, elicited a dose- and/or time-dependent attenuation of referred visceral hypersensitivity, while the ASIC blocker, amiloride, was ineffective at all doses tested.

conclusionTogether, these findings implicate opioid receptors, GC-C, and sodium and TRP channel activation as possible mechanisms associated with visceral hypersensitivity. More importantly, these findings also validate NSAID-induced gastropathy as a sensitive and clinically predictive mouse model suitable for assessing novel molecules with potential pain-attenuating properties.

Indexed as

AcetanilidesAcid Sensing Ion Channel BlockersAcid Sensing Ion ChannelsAcrylamidesAmilorideAnalgesicsAnalgesics, OpioidAnimalsAnti-Inflammatory Agents, Non-SteroidalBridged Bicyclo Compounds, HeterocyclicDisease Models, AnimalDrug Evaluation, PreclinicalHumansHyperalgesiaMaleMice2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamideAcetanilidesAcid Sensing Ion Channel BlockersAcid Sensing Ion ChannelsAcrylamidesAmilorideAnalgesicsAnalgesics, OpioidAnti-Inflammatory Agents, Non-Steroidalatrial natriuretic factor receptor CBridged Bicyclo Compounds, HeterocyclicMorphinePurinesReceptors, Atrial Natriuretic FactorReceptors, OpioidTransient Receptor Potential ChannelsGuanylate cyclase CNon-steroidal anti-inflammatory drugsPainTransient receptor potential channelTranslationVisceral hypersensitivity

Identifiers

PMID28970722
PMCPMC5597498
OpenAlexW2755341408

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.