ArticleNature communications2017
Transcriptomes and neurotransmitter profiles of classes of gustatory and somatosensory neurons in the geniculate ganglion.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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Who cites it
46 citing papers in PubMed, 77 citations in OpenAlex.
- Article
- Anatomical Characteristics of Tongue-Innervating Mechanoreceptors.The Journal of comparative neurology · 2026Article
- Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system.Nature reviews. Cardiology · 2026Review
- Research Progress on MET, Tip Link, and Stereocilia Complex with Special Reference to Zebrafish.International journal of molecular sciences · 2025Review
- Article
- Deciphering Peripheral Taste Neuron Diversity: Using Genetic Identity to Bridge Taste Bud Innervation Patterns and Functional Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The role of GABA in modulation of taste signaling within the taste bud.Pflugers Archiv : European journal of physiology · 2024Article
- Neural circuits for taste sensation.Molecules and cells · 2024Review
- Give-and-take of gustation: the interplay between gustatory neurons and taste buds.Chemical senses · 2024Review
- Rapid structural remodeling of peripheral taste neurons is independent of taste cell turnover.PLoS biology · 2023Article
- EGR4 is critical for cell-fate determination and phenotypic maintenance of geniculate ganglion neurons underlying sweet and umami taste.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Taste arbor structural variability analyzed across taste regions.The Journal of comparative neurology · 2023Article
- A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells.eNeuro · 2023Article
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- Anterior and Posterior Tongue Regions and Taste Papillae: Distinct Roles and Regulatory Mechanisms with an Emphasis on Hedgehog Signaling and Antagonism.International journal of molecular sciences · 2023Review
- Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough.ERJ open research · 2023Article
- Microfluidics for Neuronal Cell and Circuit Engineering.Chemical reviews · 2022Review
- The sense of taste: Development, regeneration, and dysfunction.WIREs mechanisms of disease · 2022Review
- Neural signalling of gut mechanosensation in ingestive and digestive processes.Nature reviews. Neuroscience · 2022Review
- Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon.Frontiers in neural circuits · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Taste buds are innervated by neurons whose cell bodies reside in cranial sensory ganglia. Studies on the functional properties and connectivity of these neurons are hindered by the lack of markers to define their molecular identities and classes. The mouse geniculate ganglion contains chemosensory neurons innervating lingual and palatal taste buds and somatosensory neurons innervating the pinna. Here, we report single cell RNA sequencing of geniculate ganglion neurons. Using unbiased transcriptome analyses, we show a pronounced separation between two major clusters which, by anterograde labeling, correspond to gustatory and somatosensory neurons. Among the gustatory neurons, three subclusters are present, each with its own complement of transcription factors and neurotransmitter response profiles. The smallest subcluster expresses both gustatory- and mechanosensory-related genes, suggesting a novel type of sensory neuron. We identify several markers to help dissect the functional distinctions among gustatory neurons and address questions regarding target interactions and taste coding.Characterization of gustatory neural pathways has suffered due to a lack of molecular markers. Here, the authors report single cell RNA sequencing and unbiased transcriptome analyses to reveal major distinctions between gustatory and somatosensory neurons and subclusters of gustatory neurons with unique molecular and functional profiles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.