ArticleScientific reports2017
Tomographic in vivo microscopy for the study of lung physiology at the alveolar level.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- In vivo imaging of central nervous system fluid spaces using synchrotron radiation-based micro computed tomography.Nature communications · 2026Article
- Ultra-high-resolution synchrotron phase-contrast CT enables microstructural pulmonary imaging at clinical dose levels.Respiratory research · 2026Article
- Synchrotron radiation based analyzer-free dual-phase dark-field lung imaging approach for radiography and CT.Scientific reports · 2025Article
- In situ propagation-based lung computed tomography for large animal models.Journal of synchrotron radiation · 2025Article
- A standing wave tube-like setup designed for tomographic imaging of the sound-induced motion patterns in fish hearing structures.BMC biology · 2025Article
- Synchrotron Radiation-Based Tomography of an Entire Mouse Brain with Sub-Micron Voxels: Augmenting Interactive Brain Atlases with Terabyte Data.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Optimising 4D imaging of fast-oscillating structures using X-ray microtomography with retrospective gating.Scientific reports · 2024Article
- Alveolar Microdynamics during Tidal Ventilation in Live Animals Imaged by SPring-8 Synchrotron.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The fix is not yet in: recommendation for fixation of lungs within physiological/pathophysiological volume range in preclinical pulmonary structure-function studies.American journal of physiology. Lung cellular and molecular physiology · 2024Review
- Article
- High resolution propagation-based lung imaging at clinically relevant X-ray dose levels.Scientific reports · 2023Article
- Deep 3D reconstruction of synchrotron X-ray computed tomography for intact lungs.Scientific reports · 2023Article
- Phase-contrast virtual chest radiography.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Simultaneous assessment of lung morphology and respiratory motion in retrospectively gated in-vivo microCT of free breathing anesthetized mice.Scientific reports · 2022Article
- Lung tissue biomechanics imaged with synchrotron phase contrast microtomography in live rats.Scientific reports · 2022Article
- Imaging Regional Lung Structure and Function in Small Animals Using Synchrotron Radiation Phase-Contrast and K-Edge Subtraction Computed Tomography.Frontiers in physiology · 2022Review
- Review
- Simple low dose radiography allows precise lung volume assessment in mice.Scientific reports · 2021Article
- Micrometer-resolution X-ray tomographic full-volume reconstruction of an intact post-mortem juvenile rat lung.Histochemistry and cell biology · 2021Article
- Three-Dimensional Whole-Organ Characterization of the Regional Alveolar Morphology in Normal Murine Lungs.Frontiers in physiology · 2021Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lungs represent the essential part of the mammalian respiratory system, which is reflected in the fact that lung failure still is one of the leading causes of morbidity and mortality worldwide. Establishing the connection between macroscopic observations of inspiration and expiration and the processes taking place at the microscopic scale remains crucial to understand fundamental physiological and pathological processes. Here we demonstrate for the first time in vivo synchrotron-based tomographic imaging of lungs with pixel sizes down to a micrometer, enabling first insights into high-resolution lung structure. We report the methodological ability to study lung inflation patterns at the alveolar scale and its potential in resolving still open questions in lung physiology. As a first application, we identified heterogeneous distension patterns at the alveolar level and assessed first comparisons of lungs between the in vivo and immediate post mortem states.
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