ArticleScientific reports2017
Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential behavioral manipulation genes and a possible major role for enterotoxins.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
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- Zombie-ant fungi from western Mexico: six new species in thePersoonia · 2025Article
- Parasitism by Entomopathogenic Fungi and Insect Host Defense Strategies.Microorganisms · 2025Review
- Viral- and fungal-mediated behavioral manipulation of hosts: summit disease.Applied microbiology and biotechnology · 2024Review
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- Genomic comparative analysis ofFrontiers in microbiology · 2024Article
- Using machine learning to predict protein-protein interactions between a zombie ant fungus and its carpenter ant host.Scientific reports · 2023Article
- Manipulative neuroparasites: uncovering the intricacies of neurological host control.Archives of microbiology · 2023Review
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- Unraveling the Secrets of a Double-Life Fungus by Genomics:Journal of fungi (Basel, Switzerland) · 2023Article
- Isolation of strains and their genome sequencing to analyze the mating system of Ophiocordyceps robertsii.PloS one · 2023Article
- Systematic analyses with genomic and metabolomic insights reveal a new species,Frontiers in microbiology · 2023Article
- Genome sequences of 24 Aspergillus niger sensu stricto strains to study strain diversity, heterokaryon compatibility, and sexual reproduction.G3 (Bethesda, Md.) · 2022Article
- High sorbic acid resistance of Penicillium roqueforti is mediated by the SORBUS gene cluster.PLoS genetics · 2022Article
- Hijacking time: How Ophiocordyceps fungi could be using ant host clocks to manipulate behavior.Parasite immunology · 2022Review
- The genus Entomophthora: bringing the insect destroyers into the twenty-first century.IMA fungus · 2021Review
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- Microbial Toxins in Insect and Nematode Pest Biocontrol.International journal of molecular sciences · 2021Review
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5 authors.
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Abstract
Much can be gained from revealing the mechanisms fungal entomopathogens employ. Especially intriguing are fungal parasites that manipulate insect behavior because, presumably, they secrete a wealth of bioactive compounds. To gain more insight into their strategies, we compared the genomes of five ant-infecting Ophiocordyceps species from three species complexes. These species were collected across three continents, from five different ant species in which they induce different levels of manipulation. A considerable number of (small) secreted and pathogenicity-related proteins were only found in these ant-manipulating Ophiocordyceps species, and not in other ascomycetes. However, few of those proteins were conserved among them, suggesting that several different methods of behavior modification have evolved. This is further supported by a relatively fast evolution of previously reported candidate manipulation genes associated with biting behavior. Moreover, secondary metabolite clusters, activated during biting behavior, appeared conserved within a species complex, but not beyond. The independent co-evolution between these manipulating parasites and their respective hosts might thus have led to rather diverse strategies to alter behavior. Our data indicate that specialized, secreted enterotoxins may play a major role in one of these strategies.
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