ArticleNature communications2017
Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- In Vivo Analysis of Medial Perforant Path-Evoked Excitation and Inhibition in Dentate Granule Cells.eNeuro · 2025Article
- Parvalbumin Interneuron-Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mystery of gamma wave stimulation in brain disorders.Molecular neurodegeneration · 2024Review
- Gamma oscillation plasticity is mediated via parvalbumin interneurons.Science advances · 2024Article
- Connectivity concepts in neuronal network modeling.PLoS computational biology · 2022Review
- Phase response approaches to neural activity models with distributed delay.Biological cybernetics · 2022Review
- Parvalbumin expressing interneurons control spike-phase coupling of hippocampal cells to theta oscillations.Scientific reports · 2022Article
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- Article
- Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories.Nature reviews. Neuroscience · 2020Review
- Presynaptic GABAeLife · 2020Article
- Tonic Resting State Hubness Supports High Gamma Activity Defined Verbal Memory Encoding Network in Epilepsy.Neuroscience · 2020Article
- GABAergic Inhibitory Interneuron Deficits in Alzheimer's Disease: Implications for Treatment.Frontiers in neuroscience · 2020Review
- Dendritic inhibition differentially regulates excitability of dentate gyrus parvalbumin-expressing interneurons and granule cells.Nature communications · 2019Article
- Macroscopic phase resetting-curves determine oscillatory coherence and signal transfer in inter-coupled neural circuits.PLoS computational biology · 2019Article
- ParvalbuminNature communications · 2018Article
- Inhibitory Interneurons Regulate Temporal Precision and Correlations in Cortical Circuits.Trends in neurosciences · 2018Review
- Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice.Journal of visualized experiments : JoVE · 2018Article
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4 authors.
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Abstract
Gamma oscillations (30-150 Hz) in neuronal networks are associated with the processing and recall of information. We measured local field potentials in the dentate gyrus of freely moving mice and found that gamma activity occurs in bursts, which are highly heterogeneous in their spatial extensions, ranging from focal to global coherent events. Synaptic communication among perisomatic-inhibitory interneurons (PIIs) is thought to play an important role in the generation of hippocampal gamma patterns. However, how neuronal circuits can generate synchronous oscillations at different spatial scales is unknown. We analyzed paired recordings in dentate gyrus slices and show that synaptic signaling at interneuron-interneuron synapses is distance dependent. Synaptic strength declines whereas the duration of inhibitory signals increases with axonal distance among interconnected PIIs. Using neuronal network modeling, we show that distance-dependent inhibition generates multiple highly synchronous focal gamma bursts allowing the network to process complex inputs in parallel in flexibly organized neuronal centers.Perisomatic-inhibitory interneurons (PIIs) contribute to the generation of gamma oscillations in the hippocampus. Here the authors demonstrate distance-dependent inhibition between PIIs in freely moving mice, and use computational analysis to show that distance-dependent inhibition supports the emergence of focal gamma bursts.
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