Evidence map›Paper›PMID 28970482›Full record

ArticleNature microbiology2017

CD14

Daniela Michlmayr, Paulina Andrade, Karla Gonzalez, Angel Balmaseda, Eva Harris

Open access · bronzeAbstract read
In one paragraph

Article in Nature microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed
23.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 202 citations in OpenAlex.

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  18. Immunocompetent mouse models revealed that S100A4Emerging microbes & infections · 2024
    Article
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Daniela MichlmayrDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, 94720-3370, CA, USA.
Paulina AndradeDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, 94720-3370, CA, USA.
Karla GonzalezSustainable Sciences Institute, Managua, 14007, Nicaragua.
Angel BalmasedaSustainable Sciences Institute, Managua, 14007, Nicaragua.
Eva HarrisDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, 94720-3370, CA, USA. eharris@berkeley.edu.ORCID http://orcid.org/0000-0002-7238-4037
National Autonomous University of Nicaragua · NIBerkeley Public Health Division · USUniversidad San Francisco de Quito · ECUniversity of California, Berkeley · US

Funding

Project 3 - Ex vivo immune profiling of dengue viruses and vaccinesU19AI118610 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI OSORIO, JORGE E · 2015 to 2021
$46.6M
T Cell Responses Following DENV Natural Infections and Live-Attenuated Dengue Virus VaccinationP01AI106695 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Daniela Weiskopf · 2015 to 2026
$34.1M
Viral Immunity and VAccination (VIVA) Human Immunology Project Consortium (HIPC)U19AI168631 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ana Fernandez-Sesma · 2022 to 2026
$14.4M
Metabolomics-based discovery of small molecule biomarkers for noninvasive dengueR33AI100186 · NIAID · COLORADO STATE UNIVERSITY · PI PERERA, RUSHIKA · 2014 to 2016
$1.3M
NIAID NIH HHS P01 AI106695NIAID NIH HHS R33 AI100186NIAID NIH HHS U19 AI118610NIAID NIH HHS U19 AI168631
6 · The paper itself

Abstract

The recent Zika pandemic in the Americas is linked to congenital birth defects and Guillain-Barré syndrome. White blood cells (WBCs) play an important role in host immune responses early in arboviral infection. Infected WBCs can also function as 'Trojan horses' and carry viruses into immune-sheltered spaces, including the placenta, testes and brain. Therefore, defining which WBCs are permissive to Zika virus (ZIKV) is critical. Here, we analyse ZIKV infectivity of peripheral blood mononuclear cells (PBMCs) in vitro and from Nicaraguan Zika patients and show CD14

Indexed as

AdolescentChemokine CXCL12Chemokines, CChildChild, PreschoolDendritic CellsDengueFemaleGPI-Linked ProteinsHumansImmunity, InnateInterferon-gammaInterleukin-10Interleukin-6Lipopolysaccharide ReceptorsMaleChemokine CXCL12Chemokines, CCXCL12 protein, humanFCGR3B protein, humanGPI-Linked ProteinsIL10 protein, humanIL6 protein, humanInterferon-gammaInterleukin-10Interleukin-6Lipopolysaccharide ReceptorsReceptors, IgGRNA, ViralXCL1 protein, human

Identifiers

PMID28970482
PMCPMC5997390
OpenAlexW2759977828

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.