ArticleNature ecology & evolution2017
Metals promote sequences of the reverse Krebs cycle.
Article in Nature ecology & evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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Who cites it
104 citing papers in PubMed, 230 citations in OpenAlex.
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- Intermediate stages in the origin of metabolism at a phosphorylating hydrothermal vent.Science advances · 2026Article
- The Emergence of Life in the Light of Evolution.ArXiv · 2026Article
- Primitive Basic Amino Acids Promote Mineral-Catalyzed Electrochemical Reduction of HThe journal of physical chemistry. C, Nanomaterials and interfaces · 2026Article
- Shadow metabolism at interfaces.Nature chemical biology · 2026Article
- A Nonenzymatic Analogue of the Biosynthesis of Pyridoxal Vitamers.Journal of the American Chemical Society · 2026Article
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- Redox chemistry of early Earth and the origin of life.Communications chemistry · 2026Review
- Mineral-facilitated aqueous synthesis of hydrogen cyanide from prebiotically abundant amino acids for chemical evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Metallic molybdenum sulfide catalyses protometabolic carbon dioxide reaction networks under extreme conditions.Nature communications · 2026Article
- Photo/Biohybrid Catalytic System for Application in Semiartificial Photosynthesis of COChemical reviews · 2026Review
- The Origin of Life and Cellular Systems: A Continuum from Prebiotic Chemistry to Biodiversity.Life (Basel, Switzerland) · 2025Article
- Autocatalytic Reaction between HCN and Cysteamine Produces Hydrophobic, Catalytic, Liquid Compartments.Journal of the American Chemical Society · 2025Article
- Thermodynamic Constraints on the Citric Acid Cycle and Related Reactions in Ocean World Interiors.ACS earth & space chemistry · 2025Article
- Abiotic origin of the citric acid cycle intermediates.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- Carbon fluxes rewiring in engineered E. coli via reverse tricarboxylic acid cycle pathway under chemolithotrophic condition.Journal of biological engineering · 2025Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The reverse tricarboxylic acid (rTCA) cycle (also known as the reverse Krebs cycle) is a central anabolic biochemical pathway whose origins are proposed to trace back to geochemistry, long before the advent of enzymes, RNA or cells, and whose imprint remains intimately embedded in the structure of core metabolism. If it existed, a primordial version of the rTCA cycle would necessarily have been catalysed by naturally occurring minerals at the earliest stage of the transition from geochemistry to biochemistry. Here, we report non-enzymatic promotion of multiple reactions of the rTCA cycle in consecutive sequence, whereby 6 of its 11 reactions were promoted by Zn
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.