ArticleThe Journal of experimental medicine2017
Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.
Open access · bronzeAbstract read
In one paragraph
Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Molecular Pathways and Circulating Biomarkers in Cerebral Cavernous Malformations-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Cerebral cavernous malformations: epidemiology, molecular pathogenesis, diagnosis and therapy.Molecular biomedicine · 2026Review
- Rapamycin Partially Reverts Cavernoma Endothelial Cell Phenotype and, When Combined With Lapatinib, Ameliorates Chronic Lesions.Journal of cellular and molecular medicine · 2026Article
- Identification of the adhesion GPCR ADGRL4/ELTD1 as a novel potential prognostic biomarker for cerebral cavernous malformation disease.Molecular medicine (Cambridge, Mass.) · 2026Article
- Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression.Nature communications · 2026Article
- Familial Cerebral Cavernous Malformations: Pathophysiology, Genetics, Biomarkers, and Treatment Perspectives.Journal of neurochemistry · 2026Review
- Integration of artificial intelligence and high-content screening enabled identification of drugs for long-term treatment of cerebral cavernous malformation disease.bioRxiv : the preprint server for biology · 2025Article
- Common and distinct circulating microRNAs in four neurovascular disorders.Biochemistry and biophysics reports · 2025Article
- Persistent Activation of Endothelial Cells is Linked to Thrombosis and Inflammation in Cerebral Cavernous Malformation Disease.bioRxiv : the preprint server for biology · 2025Article
- High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins.Angiogenesis · 2025Article
- SilencingInternational journal of molecular sciences · 2025Article
- Review
- Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Behavioral impairments are linked to neuroinflammation in mice with Cerebral Cavernous Malformation disease.bioRxiv : the preprint server for biology · 2024Article
- Circulating biomarkers in familial cerebral cavernous malformation.EBioMedicine · 2024Article
- Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation.Brain sciences · 2023Review
- Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease.Translational stroke research · 2023Article
- Endothelial hyperactivation of mutant MAP3K3 induces cerebral cavernous malformation enhanced by PIK3CA GOF mutation.Angiogenesis · 2023Article
- Impaired retinoic acid signaling in cerebral cavernous malformations.Scientific reports · 2023Article
- KRIT1: A Traffic Warden at the Busy Crossroads Between Redox Signaling and the Pathogenesis of Cerebral Cavernous Malformation Disease.Antioxidants & redox signaling · 2023Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Miguel Alejandro Lopez-RamirezDepartment of Medicine, University of California, San Diego, La Jolla, CA.
Gregory FonsecaDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA.ORCID http://orcid.org/0000-0002-3073-5724
Hussein A ZeineddineNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL.
Romuald GirardNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL.
Thomas MooreNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL.ORCID http://orcid.org/0000-0002-9540-2971
Angela PhamDepartment of Medicine, University of California, San Diego, La Jolla, CA.
Ying CaoNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL.ORCID http://orcid.org/0000-0001-9846-0176
Robert ShenkarNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL.ORCID http://orcid.org/0000-0002-1300-6845
Bart-Jan de KreukDepartment of Medicine, University of California, San Diego, La Jolla, CA.
Frederic LagarrigueDepartment of Medicine, University of California, San Diego, La Jolla, CA.
Jack LawlerDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Christopher K GlassDepartment of Medicine, University of California, San Diego, La Jolla, CA.ORCID http://orcid.org/0000-0003-4344-3592
Issam A AwadNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL.
Mark H GinsbergDepartment of Medicine, University of California, San Diego, La Jolla, CA mhginsberg@ucsd.edu.ORCID http://orcid.org/0000-0002-5685-5417
University of California San Diego · USUniversity of Chicago · USBeth Israel Deaconess Medical Center · US
Funding
The Interaction of TPO and Integrins in Hematopoiesis CellsP01HL078784 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GINSBERG, MARK HOWARD · 2005 to 2019
$28.3MTranscriptional GenomicsP01HL088093 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2008 to 2018
$26.4MSomatic mutation(s) and cellular changes in CCM pathogenesisP01NS092521 · NINDS · DUKE UNIVERSITY · PI KAHN, MARK L · 2015 to 2024
$12.9MU of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0MDeconvoluting the Vascular AdhesomeR35HL139947 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GINSBERG, MARK HOWARD · 2018 to 2024
$5.5MKRIT1 and Vascular IntegrityR01HL106489 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GINSBERG, MARK HOWARD · 2011 to 2017
$2.3MRegulation of endothelial gene expression by cerebral cavernous malformation complexK01HL133530 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOPEZ-RAMIREZ, MIGUEL ALEJANDRO · 2018 to 2022
$903kNHLBI NIH HHS K01 HL133530NHLBI NIH HHS P01 HL078784NHLBI NIH HHS P01 HL088093NHLBI NIH HHS R01 HL106489NHLBI NIH HHS R35 HL139947NINDS NIH HHS P01 NS092521NINDS NIH HHS P30 NS047101
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsCells, CulturedEndothelial CellsGene Expression ProfilingGenetic TherapyHEK293 CellsHemangioma, Cavernous, Central Nervous SystemHumansKRIT1 ProteinKruppel-Like Factor 4Kruppel-Like Transcription FactorsMice, Inbred C57BLMice, KnockoutMice, TransgenicRNA InterferenceThrombospondin 1Klf2 protein, mouseKLF4 protein, humanKlf4 protein, mouseKRIT1 ProteinKruppel-Like Factor 4Kruppel-Like Transcription FactorsThbs1 protein, mouseThrombospondin 1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.