ArticleThe Journal of experimental medicine2017
HCFC2 is needed for IRF1- and IRF2-dependent
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In one paragraph
Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Genome-wide screen inbioRxiv : the preprint server for biology · 2025Article
- Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration.Journal of neuroinflammation · 2025Article
- Genomic insights into runs of homozygosity, effective population size and selection signatures in Iranian meat and dairy sheep breeds.PloS one · 2025Article
- Transcriptional control of interferon-stimulated genes.The Journal of biological chemistry · 2024Review
- IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis.Molecular medicine reports · 2022Article
- IRF2-induced Claudin-7 suppresses cell proliferation, invasion and migration of oral squamous cell carcinoma.Experimental and therapeutic medicine · 2022Article
- IRF2 is required for development and functional maturation of human NK cells.Frontiers in immunology · 2022Article
- Transcriptomic profiling and genomic mutational analysis of Human coronavirus (HCoV)-229E -infected human cells.PloS one · 2021Article
- Article
- TRIM14 expression is regulated by IRF-1 and IRF-2.FEBS open bio · 2019Article
- HCF-2 inhibits cell proliferation and activates differentiation-gene expression programs.Nucleic acids research · 2019Article
- Type I interferon signaling, regulation and gene stimulation in chronic virus infection.Seminars in immunology · 2019Review
- IRF1 Maintains Optimal Constitutive Expression of Antiviral Genes and Regulates the Early Antiviral Response.Frontiers in immunology · 2019Article
- Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Insights into the pathogenesis of herpes simplex encephalitis from mouse models.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Innate immunity and the new forward genetics.Best practice & research. Clinical haematology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 3 institutions in 1 country.
Lei SunCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.
Zhengfan JiangDepartment of Genetics, The Scripps Research Institute, La Jolla, CA.
Victoria A Acosta-RodriguezDepartment of Neuroscience, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX.
Michael BergerDepartment of Genetics, The Scripps Research Institute, La Jolla, CA.
Xin DuDepartment of Genetics, The Scripps Research Institute, La Jolla, CA.ORCID http://orcid.org/0000-0003-2339-8464
Jin Huk ChoiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.ORCID http://orcid.org/0000-0003-2483-4379
Jianhui WangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.
Kuan-Wen WangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.ORCID http://orcid.org/0000-0001-9711-7296
Gokhul K KilaruDepartment of Neuroscience, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX.
Jennifer A MohawkDepartment of Neuroscience, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX.ORCID http://orcid.org/0000-0003-3192-8015
Jiexia QuanCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.
Lindsay ScottCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.ORCID http://orcid.org/0000-0003-4243-4010
Sara HildebrandCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.
Xiaohong LiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.
Miao TangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.
Xiaoming ZhanCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.
Anne R MurrayCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.
Diantha La VineCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.
Eva Marie Y MorescoCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX.ORCID http://orcid.org/0000-0002-2049-7291
Joseph S TakahashiDepartment of Neuroscience, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX.ORCID http://orcid.org/0000-0003-0384-8878
Bruce BeutlerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX bruce.beutler@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-3639-246X
The University of Texas Southwestern Medical Center · USHoward Hughes Medical Institute · USScripps Research Institute · US
Funding
Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NOLAN, GARRY P · 2012 to 2021
$49.1MNIAID NIH HHS U19 AI100627
Abstract
Transcriptional regulation of numerous interferon-regulated genes, including
Indexed as
AnimalsCell Line, TumorFemaleGene Expression RegulationHEK293 CellsHerpes SimplexHerpesvirus 1, HumanHumansInfluenza A Virus, H1N1 SubtypeInterferon Regulatory Factor-1Interferon Regulatory Factor-2Kaplan-Meier EstimateMacrophagesMaleMiceMice, Inbred C57BLHcfc2 protein, mouseInterferon Regulatory Factor-1Interferon Regulatory Factor-2Irf1 protein, mousePoly I-CToll-Like Receptor 3Transcription Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.