ArticleAmerican journal of surgery2017
Targeting resuscitation to normalization of coagulating status: Hyper and hypocoagulability after severe injury are both associated with increased mortality.
Article in American journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Platelet clotting defects in severe trauma identified by a whole blood microfluidic assay.Transfusion · 2026Article
- Targeting Inflammation After Hemorrhagic Shock as a Molecular and Experimental Journey to Improve Outcomes: A Review.Cureus · 2025Review
- Integrated proteomic and metabolomic profiling of lymph after trauma-induced hypercoagulopathy and antithrombotic therapy.Thrombosis journal · 2024Article
- Whole Blood Thrombin Generation in Severely Injured Patients Requiring Massive Transfusion.Journal of the American College of Surgeons · 2021Article
- Trauma-induced coagulopathy.Nature reviews. Disease primers · 2021Review
- Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy.Military Medical Research · 2021Article
- Hypercoagulability in pregnant trauma patients.Trauma surgery & acute care open · 2021Article
- Actin is associated with tissue injury in trauma patients and produces a hypercoagulable profile in vitro.The journal of trauma and acute care surgery · 2020Article
- Modern Management of Bleeding, Clotting, and Coagulopathy in Trauma Patients: What Is the Role of Viscoelastic Assays?Current trauma reports · 2020Article
- How to detect a polytrauma patient at risk of complications: A validation and database analysis of four published scales.PloS one · 2020Article
- Whole blood thrombin generation is distinct from plasma thrombin generation in healthy volunteers and after severe injury.Surgery · 2019Article
- Response to Letter to the Editor submitted by Dr. Wada and Dr. Yamakawa re: Trauma-induced coagulopathy: The past, present, and future.Journal of thrombosis and haemostasis : JTH · 2019Article
- The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management.Korean journal of anesthesiology · 2019Review
- Trauma Resuscitation Consideration: Sex Matters.Journal of the American College of Surgeons · 2019Article
- Microfluidics contrasted to thrombelastography: perplexities in defining hypercoagulability.The Journal of surgical research · 2018Article
- Dynamic coagulability after injury: Is delaying venous thromboembolism chemoprophylaxis worth the wait?The journal of trauma and acute care surgery · 2018Article
- Article
- Goal-directed hemostatic resuscitation for trauma induced coagulopathy: Maintaining homeostasis.The journal of trauma and acute care surgery · 2018Article
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9 authors at 3 institutions in 1 country.
Funding
Abstract
introductionThe prevalence and impact of hypercoagulability (hypo) in severely injured patients early after injury remains unclear. We hypothesize that the predominant phenotype of postinjury coagulopathy is hypercoagulability (hyper) and it is associated with increased mortality. MATERIAL AND
methodsBlood samples from 141 healthy volunteers assayed with thrombelastography (TEG) were used to identify thresholds of hypo and hypercoagulability (above 95th/below the 5
results2540 patients with a median ISS of 25 were analyzed. Normal TEG was present in 36% of patients. Hyper was found in 38% of patients, with mixed (11%) and hypo (15%) being less common. Compared to normal coagulation patients and after controlling for age, sex, blood pressure, and injury hyper (0.013), mixed (p < 0.001) and hypo (p < 0.001) were all independent predictors of mortality.
conclusionThese data support the ongoing need for goal directed resuscitation in trauma patients, it appears the optimal resuscitation strategy should be targeted towards normalization of coagulation status as both early hyper and hypocoagulability are associated with increased mortality.
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