ArticlePsychological medicine2018
Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women.
Article in Psychological medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Depression and glioblastoma, complicated concomitant diseases: a systemic review of published literature.Neurosurgical review · 2020Pooled it
- Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.Molecular psychiatry · 2025Article
- Divorce, genetic risk, and suicidal thoughts and behaviors in a sample with recurrent major depressive disorder.Journal of affective disorders · 2024Article
- Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.medRxiv : the preprint server for health sciences · 2023Article
- Childhood urbanicity interacts with polygenic risk for depression to affect stress-related medial prefrontal function.Translational psychiatry · 2021Article
- Pathway-based polygene risk for severe depression implicates drug metabolism in CONVERGE.Psychological medicine · 2020Article
- Age of onset and family history as indicators of polygenic risk for major depression.Depression and anxiety · 2017Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies have demonstrated that several major psychiatric disorders are influenced by shared genetic factors. This shared liability may influence clinical features of a given disorder (e.g. severity, age at onset). However, findings have largely been limited to European samples; little is known about the consistency of shared genetic liability across ethnicities.
methodThe relationship between polygenic risk for several major psychiatric diagnoses and major depressive disorder (MDD) was examined in a sample of unrelated Han Chinese women. Polygenic risk scores (PRSs) were generated using European discovery samples and tested in the China, Oxford, and VCU Experimental Research on Genetic Epidemiology [CONVERGE (maximum N = 10 502)], a sample ascertained for recurrent MDD. Genetic correlations between discovery phenotypes and MDD were also assessed. In addition, within-case characteristics were examined.
resultsEuropean-based polygenic risk for several major psychiatric disorder phenotypes was significantly associated with the MDD case status in CONVERGE. Risk for clinically significant indicators (neuroticism and subjective well-being) was also associated with case-control status. The variance accounted for by PRS for both psychopathology and for well-being was similar to estimates reported for within-ethnicity comparisons in European samples. However, European-based PRS were largely unassociated with CONVERGE family history, clinical characteristics, or comorbidity.
conclusionsThe shared genetic liability across severe forms of psychopathology is largely consistent across European and Han Chinese ethnicities, with little attenuation of genetic signal relative to within-ethnicity analyses. The overall absence of associations between PRS for other disorders and within-MDD variation suggests that clinical characteristics of MDD may arise due to contributions from ethnicity-specific factors and/or pathoplasticity.
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