ArticleRadiation oncology (London, England)2017
Exclusion of emphysematous lung from dose-volume estimates of risk improves prediction of radiation pneumonitis.
Article in Radiation oncology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- The impact of pre-existing interstitial lung disease on radiation and checkpoint inhibitor pneumonitis in lung cancer patients: a systematic review and meta-analysis.Therapeutic advances in medical oncology · 2025Article
- The incidence of and risk factors for radiation pneumonitis in patients treated with simultaneous bevacizumab and thoracic radiotherapy.Radiation oncology (London, England) · 2024Article
- Hyperacute Radiation Pneumonitis after Severe irAE.Diagnostics (Basel, Switzerland) · 2024Article
- A case report of successful treatment of advanced thymic squamous cell carcinoma with poor performance status using multimodal therapy.Frontiers in oncology · 2024Article
- Re-evaluating the risk factors for radiation pneumonitis in the era of immunotherapy.Journal of translational medicine · 2023Review
- A deep learning method for translating 3DCT to SPECT ventilation imaging: First comparison withMedical physics · 2022Article
- Risk factors for pneumonitis in advanced extrapulmonary cancer patients treated with immune checkpoint inhibitors.BMC cancer · 2022Article
- Research Progress on Radiotherapy Combined with Immunotherapy for Associated Pneumonitis During Treatment of Non-Small Cell Lung Cancer.Cancer management and research · 2022Review
- High incidence of radiation pneumonitis in lung cancer patients with chronic silicosis treated with radiotherapy.Journal of radiation research · 2020Article
- Observational
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12 authors.
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Abstract
backgroundThe risk factors for radiation pneumonitis (RP) in patients with chronic obstructive pulmonary disease (COPD) are unclear. Mean lung dose (MLD) and percentage of irradiated lung volume are common predictors of RP, but the most accurate dosimetric parameter has not been established. We hypothesized that the total lung volume irradiated without emphysema would influence the onset of RP.
methodsWe retrospectively evaluated 100 patients who received radiotherapy for lung cancer. RP was graded according to the Common Terminology Criteria for Adverse Events (version 4.03). We quantified low attenuation volume (LAV) using quantitative computed tomography analysis. The association between RP and traditional dosimetric parameters including MLD, volume of the lung receiving a dose of ≥2 Gy, ≥ 5 Gy, ≥ 10 Gy, ≥ 20 Gy, and ≥30 Gy, and counterpart measurements of the lung without LAV, were analyzed by logistic regression. We compared each dosimetric parameter for RP using multiple predictive performance measures including area under the receiver operating characteristic curve (AUC) and integrated discrimination improvement (IDI).
resultsOf 100 patients, RP of Grades 1, 2, 3, 4, and 5 was diagnosed in 24, 12, 13, 1, and 1 patients, respectively. Compared with traditional dosimetric parameters, counterpart measurements without LAV improved risk prediction of symptomatic RP. The ratio of the lung without LAV receiving ≥30 Gy to the total lung volume without LAV most accurately predicted symptomatic RP (AUC, 0.894; IDI, 0.064).
conclusionIrradiated lung volume without LAV predicted RP more accurately than traditional dosimetric parameters.
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