Evidence map›Paper›PMID 28969648›Full record

ReviewReproductive biology and endocrinology : RB&E2017

Ooplasmic transfer in human oocytes: efficacy and concerns in assisted reproduction.

Sara Darbandi, Mahsa Darbandi, Hamid Reza Khorram Khorshid, Mohammad Reza Sadeghi, Ashok Agarwal, Pallav Sengupta, Safaa Al-Hasani, Mohammad Mehdi Akhondi

Open access · goldAbstract readReview
In one paragraph

Review in Reproductive biology and endocrinology : RB&E, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. The Mammalian Oocyte: A Central Hub for Cellular Reprogramming and Stemness.Stem cells and cloning : advances and applications · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. The Role of CaFrontiers in cell and developmental biology · 2021
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Sara DarbandiReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Mahsa DarbandiReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Hamid Reza Khorram KhorshidGenetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Mohammad Reza SadeghiReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Ashok AgarwalCenter for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
Pallav SenguptaPhysiology Unit Faculty of Medicine Lincoln University College, Petaling Jaya, Malaysia.
Safaa Al-HasaniReproductive Medicine Unit, University of Schleswig-Holstein, Luebeck, Germany.
Mohammad Mehdi AkhondiReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. Akhondi@Avicenna.ac.ir.
Academic Center for Education, Culture and Research · IRBiotechnology Research Center · IRCleveland Clinic · USLincoln University College · MYUniversity Hospital Schleswig-Holstein · DEUniversity of Social Welfare and Rehabilitation Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOoplasmic transfer (OT) technique or cytoplasmic transfer is an emerging technique with relative success, having a significant status in assisted reproduction. This technique had effectively paved the way to about 30 healthy births worldwide. Though OT has long been invented, proper evaluation of the efficacy and risks associated with this critical technique has not been explored properly until today. This review thereby put emphasis upon the applications, efficacy and adverse effects of OT techniques in human. MAIN BODY: Available reports published between January 1982 and August 2017 has been reviewed and the impact of OT on assisted reproduction was evaluated. The results consisted of an update on the efficacy and concerns of OT, the debate on mitochondrial heteroplasmy, apoptosis, and risk of genetic and epigenetic alteration. SHORT

conclusionThe application of OT technique in humans demands more clarity and further development of this technique may successfully prove its utility as an effective treatment for oocyte incompetence.

Indexed as

Reproductive Techniques, AssistedCytoplasmEmbryo, MammalianFemaleGenes, MitochondrialHumansMitochondriaOocyte DonationOocytesTreatment OutcomeApoptosisEpigenetic modificationsGenetic modificationsMitochondriaOoplasmic transfer

Identifiers

PMID28969648
PMCPMC5625659
OpenAlexW2760238871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.