ArticleBMC urology2017
Positive surgical margins and biochemical recurrence following minimally-invasive radical prostatectomy - An analysis of outcomes from a UK tertiary referral centre.
Article in BMC urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Perioperative, functional, and oncologic outcomes in patients undergoing robot-assisted radical prostatectomy previous transurethral resection of prostate: a systematic review and meta-analysis of comparative trials.Journal of robotic surgery · 2023Pooled it
- Lower vs standard pressure pneumoperitoneum in robotic-assisted radical prostatectomy: a systematic review and meta-analysis.Journal of robotic surgery · 2023Pooled it
- Erectile function, urinary continence and oncologic outcomes of neurovascular bundle sparing robot-assisted radical prostatectomy for high-risk prostate cancer: A systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Clinicopathological Significances of Positive Surgical Resection Margin after Radical Prostatectomy for Prostatic Cancers: A Meta-Analysis.Medicina (Kaunas, Lithuania) · 2022Pooled it
- The cost-effectiveness of intraoperative margin assessment strategies during radical prostatectomy.BJU international · 2026Article
- Predictors of positive surgical margins after robot-assisted radical prostatectomy. A prospective cohort study and a systematic review with meta-analysis.Central European journal of urology · 2026Article
- Whole-mount histopathology as spatial ground truth for artificial intelligence in prostate cancer: a structured narrative review of techniques, models, and translational gaps.American journal of clinical and experimental urology · 2026Review
- Positive surgical margin and oncological outcomes after robot-assisted radical prostatectomy in different Cancer of the Prostate Risk Assessment risk groups.BJU international · 2025Article
- Bilateral Seminal Vesicle Invasion as a Strong Prognostic Indicator in T3b Prostate Cancer Patients Following Radical Prostatectomy: A Comprehensive, Multicenter, Long-term Follow-up Study.Cancer research and treatment · 2024Article
- Retrotrigonal Layer Dissection from a Posterior Approach Enables Bladder Neck Preservation in Robot-Assisted Radical Prostatectomy.Journal of clinical medicine · 2024Article
- Imaging classification of prostate cancer with extracapsular extension and its impact on positive surgical margins after laparoscopic radical prostatectomy.Frontiers in oncology · 2024Article
- Point-of-Care Prostate Specific Antigen Testing: Examining Translational Progress toward Clinical Implementation.ACS sensors · 2023Review
- Case Report: Analysis of four cases of metastatic bladder masses after radical prostatectomy.Frontiers in oncology · 2023Article
- Analysis of risk factors for positive surgical margin after laparoscopic radical prostatectomy with and without neoadjuvant hormonal therapy.Frontiers in endocrinology · 2023Article
- A comparative evaluation of radical prostatectomy using laparoscopic and open method in view of surgical margins.Central European journal of urology · 2023Article
- The Effect of Adverse Surgical Margins on the Risk of Biochemical Recurrence after Robotic-Assisted Radical Prostatectomy.Biomedicines · 2022Article
- Genetic variant located on chromosome 17p12 contributes to prostate cancer onset and biochemical recurrence.Scientific reports · 2022Article
- Width of spared neurovascular bundle after robot-assisted laparoscopic prostatectomy in patients with prostate cancer: is it a reliable factor for predicting postoperative sexual outcome?Prostate international · 2021Article
- Combined Systematic and MRI-US Fusion Prostate Biopsy Has the Highest Grading Accuracy When Compared to Final Pathology.Medicina (Kaunas, Lithuania) · 2021Article
- Is the use of ultra-low insufflation pressure safe and feasible in robot assisted radical prostatectomy.Turkish journal of urology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPositive surgical margins are a strong prognostic marker of disease outcome following radical prostatectomy, though prior evidence is largely from a PSA-screened population. We therefore aim to evaluate the biochemical recurrence in men with positive surgical margins (PSM) after minimally-invasive radical prostatectomy (MIRP) in a UK tertiary centre.
methodsRetrospective study of men undergoing laparoscopic or robotic-assisted radical prostatectomy between 2002 and 2014. Men with positive surgical margins (PSM) were identified and their biochemical recurrence (BCR) rate compared with men without PSM. The primary outcome measures were BCR rates and time to BCR. Cox regression was used to estimate adjusted hazard ratios for biochemical recurrence rate (BCR), accounting for potential confounders.
resultsFive hundred ninety-two men were included for analysis. Pre-operative D'Amico risk stratification showed 37.5%, 53.3% and 9.3% of patients in the low, intermediate and high-risk groups, respectively. On final pathological analysis, the proportion of patients with local staging pT2, pT3a and pT3b was 68.8%, 25.2% and 6.1% respectively. Overall positive margin rate was 30.6%. On multivariate analysis, the only pre-operative factor associated with PSM was age >65years. Patients with PSM were more likely to have higher tumour volume and more advanced pathological local stage. The BCR rate was 10.7% in margin-positive patients and 5.1% in margin-negative patients, at median 4.4-year follow-up. Upon multivariate analysis, high pre-operative PSA and high Gleason group were the only significant predictors of BCR (P<0.05).
conclusionsIn comparison to patients with negative surgical margins, those with PSM do not translate into worse medium-term oncological outcomes in the majority of cases amongst our cohort. We found that high pre-operative PSA and high Gleason group were the only significant predictors of BCR.
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