Evidence map›Paper›PMID 28969269›Full record

ArticleJournal of clinical and diagnostic research : JCDR2017

Role of Cathepsin B as a Marker of Malignant Transformation in Oral Lichen Planus: An Immunohistochemical Study.

Krishnanand Prakash Satelur, Shiny Bopaiah, Radhika Manoj Bavle, Prashant Ramachandra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Lichen Planus.Frontiers in medicine · 2021
    Review
  6. Expression of Cathepsin B and Cystatin A in Oral Lichen Planus.Journal of International Society of Preventive & Community Dentistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Krishnanand Prakash SatelurProfessor, Department of Oral Pathology, Krishnadevaraya College of Dental Sciences, Bengaluru, Karnataka, India.
Shiny BopaiahPostgraduate Student, Department of Oral Pathology, Krishnadevaraya College of Dental Sciences, Bengaluru, Karnataka, India.
Radhika Manoj BavleProfessor and Head, Department of Oral Pathology, Krishnadevaraya College of Dental Sciences, Bengaluru, Karnataka, India.
Prashant RamachandraReader, Department of Oral Pathology, Krishnadevaraya College of Dental Sciences, Bengaluru, Karnataka, India.
Krishnadevaraya College of Dental Sciences and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMalignant transformation of Oral Lichen Planus (OLP) remains a much discussed but very less understood realm. Various hypotheses and theories have been put forward to explain the same. Malignant transformation is a complex interplay of epithelial mesenchymal factors acting in tandem. This study tries to identify and asses the stromal changes that pave the way for epithelial migration using Cathepsin B (CB) a cysteine protease belonging to the Cathepsin family. Various studies have been done to study its role in human cancers which have proven that CB helps mark and identify tissue digestion.

aimThe purpose of this study was to evaluate the expression of CB, in OLP and examine its possible role in malignant transformation. MATERIALS AND

methodsImmunohistochemical analysis of CB expression was done in 50 OLP tissues along with 10 normal mucosa tissue and 10 Oral Squamous Cell Carcinoma (OSCC) cases (control groups). Evaluation was done on the basis of intensity of staining. The intensity was graded in all the cases by assigning values of 0 to 4 in ascending order. Two other observers evaluated the staining and intensity independently and the average of the observations was taken.

resultsA variable staining pattern in both the stroma and the cytoplasm of the epithelial cells was noticed. The staining intensity was clearly increased in OLP tissues when compared to normal control tissue and OSCC which served as our positive control. The staining patterns in tissues of OLP and OSCC to Cathepsin B were similar. The staining intensity of Cathepsin B was observed to be increased in both these groups of tissues.

conclusionThis study demonstrated a significantly increased expression of CB in OLP. This may be correlated to a possible indicator for its eventual malignant transformation. This overexpression of CB amounts to an array of stromal changes that take place and different mechanisms that get activated underneath the epithelium leading to the formation of what is known as a tumour microenvironment, a well proven entity. We hypothesize that it is this which felicitates the invasion of the overlying epithelial cells.

Indexed as

Cysteine proteasesOral squamous cell carcinomaTumour microenvironment

Identifiers

PMID28969269
PMCPMC5620916
OpenAlexW2754503703

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.