Evidence map›Paper›PMID 28969033›Full record

ArticleOncotarget2017

GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior.

Céline Pinheiro, Sara Granja, Adhemar Longatto-Filho, André M Faria, Maria C B V Fragoso, Silvana M Lovisolo, Murilo Bonatelli, Ricardo F A Costa, Antonio M Lerário, Madson Q Almeida and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Low Protein Expression of bothInternational journal of molecular sciences · 2021
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Céline Pinheiro *Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Sara Granja *Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Adhemar Longatto-FilhoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
André M FariaUnidade de Suprarrenal, Disciplina de Endocrinologia e Metabologia, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Maria C B V FragosoUnidade de Suprarrenal, Disciplina de Endocrinologia e Metabologia, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Silvana M LovisoloHospital Universitário, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Murilo BonatelliMolecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil.
Ricardo F A CostaBarretos School of Health Sciences Dr. Paulo Prata - FACISB, São Paulo, Brazil.
Antonio M LerárioDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA.
Madson Q AlmeidaUnidade de Suprarrenal, Disciplina de Endocrinologia e Metabologia, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Fátima Baltazar *Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Maria C N Zerbini *Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
University of Minho · PTHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade de São Paulo · BRHospital São Paulo · BRInstituto do Câncer do Estado de São Paulo · BRUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiscrimination between benign and malignant tumors is a challenging process in pediatric adrenocortical tumors. New insights in the metabolic profile of pediatric adrenocortical tumors may contribute to this distinction, predict prognosis, as well as identify new molecular targets for therapy. The aim of this work is to characterize the expression of the metabolism-related proteins MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX in a series of pediatric adrenocortical tumors.

methodsA total of 50 pediatric patients presenting adrenocortical tumors, including 41 clinically benign and 9 clinically malignant tumors, were included. Protein expression was evaluated using immunohistochemistry in samples arranged in tissue microarrays.

resultsThe immunohistochemical analysis showed a significant increase in plasma membrane expression of GLUT1 in malignant lesions, when compared to benign lesions (

conclusionGLUT1 expression was differentially expressed in pediatric adrenocortical tumors, with higher expression in clinically malignant tumors, and associated with shorter survival, suggesting a metabolic remodeling towards a hyperglycolytic phenotype in this malignancy.

Indexed as

glucose transportermetabolic reprogrammingmonocarboxylate transporterpediatric adrenocortical tumorsWarburg effect

Identifiers

PMID28969033
PMCPMC5609965
OpenAlexW2735234045

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.