Evidence map›Paper›PMID 28968908›Full record

ArticleThe Journal of infectious diseases2017

Measles Antibodies in Mother-Infant Dyads in Tianjin, China.

Matthew L Boulton, Xiexiu Wang, Abram L Wagner, Ying Zhang, Bradley F Carlson, Brenda W Gillespie, Yaxing Ding

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Matthew L BoultonDepartment of Epidemiology, School of Public Health.
Xiexiu WangDivision of Expanded Programs on Immunization, Tianjin Centers for Disease Control and Prevention, China.
Abram L WagnerDepartment of Epidemiology, School of Public Health.
Ying ZhangDivision of Expanded Programs on Immunization, Tianjin Centers for Disease Control and Prevention, China.
Bradley F CarlsonDepartment of Epidemiology, School of Public Health.
Brenda W GillespieDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor.
Yaxing DingDivision of Expanded Programs on Immunization, Tianjin Centers for Disease Control and Prevention, China.
Tianjin Centers for Disease Control and Prevention · CNOffice of Infectious Diseases · USUniversity of Michigan–Ann Arbor · US

Funding

International Collaborations in Infectious Disease Research (ICIDR) (U01)U01AI088671 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOULTON, MATTHEW LESTER · 2010 to 2014
$3.6M
NIAID NIH HHS U01 AI088671
6 · The paper itself

Abstract

Background: Many measles cases in Tianjin, China, occur in infants whose mothers were born after widespread vaccination programs. We assessed age-specific decreases in maternal measles antibodies in infants and examined maternal and infant characteristics in relation to infant antibody titers. Methods: Infant and mother dyads were enrolled from a sample of immunization clinics in all Tianjin districts. Participants' antibody titers were measured from dried blood spots. A multivariable log-linear model regressed infant antibody titers onto infant and mother characteristics. Results: Among 551 infants aged ≤8 months, protective levels of measles antibodies were observed in infants whose mothers had measles titers ≥800 IU/mL (mean antibody titer, 542.5 IU/mL) or 400 to <800 IU/mL (mean, 202.2 IU/mL). Compared with infants whose mothers had no history of disease or vaccination, those with a history of disease had 1.60 times higher titers (95% confidence interval, 1.06-2.43). Conclusions: Limited vaccination programs in the 1980s have resulted in many Chinese women with inadequate protection against measles and an accordingly low efficiency of transplacental transmission to a fetus. Current vaccination programs, which target children aged 8 months through adolescence may be ineffective in controlling transmission of measles to infants.

Indexed as

AdultAntibodies, ViralChinaFemaleHumansImmunity, Maternally-AcquiredInfantInfant, NewbornMaleMeaslesMeasles virusMothersAntibodies, ViralChinamaternal antibodiesmeasles

Identifiers

PMID28968908
PMCPMC5853645
OpenAlexW2751626846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.