ArticleCerebral cortex (New York, N.Y. : 1991)2018
Denser Growing Fiber Connections Induce 3-hinge Gyral Folding.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- A Mechanical Theory for the Formation of Short Association Fibers in the Brain.bioRxiv : the preprint server for biology · 2026Article
- DEEP-GYRALNET: ENABLING MACHINE LEARNING IN GYRAL FOLDING PATTERN EXTRACTION ON CORTICAL SURFACE.Proceedings. IEEE International Symposium on Biomedical Imaging · 2026Article
- Mechanics of the Spatiotemporal Evolution of Sulcal Pits in the Folding Brain.Human brain mapping · 2025Article
- Exploring hyperelastic material model discovery for human brain cortex: Multivariate analysis vs. artificial neural network approaches.Journal of the mechanical behavior of biomedical materials · 2025Article
- USING STRUCTURAL SIMILARITY AND KOLMOGOROV-ARNOLD NETWORKS FOR ANATOMICAL EMBEDDING OF CORTICAL FOLDING PATTERNS.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025Article
- Stress landscape of folding brain serves as a map for axonal pathfinding.Nature communications · 2025Article
- Learning lifespan brain anatomical correspondence via cortical developmental continuity transfer.Medical image analysis · 2025Article
- Unique longitudinal contributions of sulcal interruptions to reading acquisition in children.bioRxiv : the preprint server for biology · 2024Article
- Frequency-specific functional difference between gyri and sulci in naturalistic paradigm fMRI.Brain structure & function · 2024Article
- Mechanical hierarchy in the formation and modulation of cortical folding patterns.Scientific reports · 2023Article
- An integrated finite element method and machine learning algorithm for brain morphology prediction.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Gyral peaks and patterns in human brains.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Cortex2vector: anatomical embedding of cortical folding patterns.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Depicting the anatomy of the gyral white matter:Brain communications · 2023Review
- Identification for the cortical 3-Hinges folding pattern based on cortical morphological and structural features.Frontiers in neuroscience · 2023Article
- Gyral peaks: Novel gyral landmarks in developing macaque brains.Human brain mapping · 2022Article
- Cortical development coupling between surface area and sulcal depth on macaque brains.Brain structure & function · 2022Article
- Fundamental functional differences between gyri and sulci: implications for brain function, cognition, and behavior.Psychoradiology · 2021Review
- Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition.Cerebral cortex communications · 2021Article
- Identifying Cross-individual Correspondences of 3-hinge Gyri.Medical image analysis · 2020Article
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Authors and funding
10 authors.
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Abstract
Recent studies have shown that quantitative description of gyral shape patterns offers a novel window to examine the relationship between brain structure and function. Along this research line, this paper examines a unique and interesting type of cortical gyral region where 3 different gyral crests meet, termed 3-hinge gyral region. We extracted 3-hinge gyral regions in macaque/chimpanzee/human brains, quantified and compared the relevant DTI-derived fiber densities in 3-hinge and 2-hinge gyral regions. Our observations consistently showed that DTI-derived fiber densities in 3-hinge regions are much higher than those in 2-hinge regions. Therefore, we hypothesize that besides the cortical expansion, denser fiber connections can induce the formation of 3-hinge gyri. To examine the biomechanical basis of this hypothesis, we constructed a series of 3-dimensional finite element soft tissue models based on continuum growth theory to investigate fundamental biomechanical mechanisms of consistent 3-hinge gyri formation. Our computational simulation results consistently showed that during gyrification gyral regions with higher concentrations of growing axonal fibers tend to form 3-hinge gyri. Our integrative approach combining neuroimaging data analysis and computational modeling appears effective in probing a plausible theory of 3-hinge gyri formation and providing new insights into structural and functional cortical architectures and their relationship.
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