Evidence map›Paper›PMID 28968762›Full record

ArticleBriefings in bioinformatics2019

PATRIC as a unique resource for studying antimicrobial resistance.

Dionysios A Antonopoulos, Rida Assaf, Ramy Karam Aziz, Thomas Brettin, Christopher Bun, Neal Conrad, James J Davis, Emily M Dietrich, Terry Disz, Svetlana Gerdes and 19 more

Abstract read
In one paragraph

Article in Briefings in bioinformatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Prediction of antimicrobial resistance inMicrobiology spectrum · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Computational and structural biotechnology journal · 2025
    Article
  13. Article
  14. Diosgenin producingComputational and structural biotechnology journal · 2025
    Article
  15. Pathogenomic Insights intoLife (Basel, Switzerland) · 2024
    Article
  16. Genome-Guided Identification of Surfactin-ProducingInternational journal of molecular sciences · 2024
    Article
  17. Article
  18. Comprehensive Genomic Analysis of UropathogenicPathogens (Basel, Switzerland) · 2024
    Article
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Dionysios A Antonopoulos
Rida Assaf
Ramy Karam Aziz
Thomas Brettin
Christopher Bun
Neal Conrad
James J Davis
Emily M Dietrich
Terry Disz
Svetlana Gerdes
Ronald W Kenyon
Dustin Machi
Chunhong Mao
Daniel E Murphy-Olson
Eric K Nordberg
Gary J Olsen
Robert Olson
Ross Overbeek
Bruce Parrello
Gordon D Pusch
John Santerre
Maulik Shukla
Rick L Stevens
Margo VanOeffelen
Veronika Vonstein
Andrew S Warren
Alice R Wattam
Fangfang Xia
Hyunseung Yoo

Funding

NIAID NIH HHS HHSN272201400027C
6 · The paper itself

Abstract

The Pathosystems Resource Integration Center (PATRIC, www.patricbrc.org) is designed to provide researchers with the tools and services that they need to perform genomic and other 'omic' data analyses. In response to mounting concern over antimicrobial resistance (AMR), the PATRIC team has been developing new tools that help researchers understand AMR and its genetic determinants. To support comparative analyses, we have added AMR phenotype data to over 15 000 genomes in the PATRIC database, often assembling genomes from reads in public archives and collecting their associated AMR panel data from the literature to augment the collection. We have also been using this collection of AMR metadata to build machine learning-based classifiers that can predict the AMR phenotypes and the genomic regions associated with resistance for genomes being submitted to the annotation service. Likewise, we have undertaken a large AMR protein annotation effort by manually curating data from the literature and public repositories. This collection of 7370 AMR reference proteins, which contains many protein annotations (functional roles) that are unique to PATRIC and RAST, has been manually curated so that it projects stably across genomes. The collection currently projects to 1 610 744 proteins in the PATRIC database. Finally, the PATRIC Web site has been expanded to enable AMR-based custom page views so that researchers can easily explore AMR data and design experiments based on whole genomes or individual genes.

Indexed as

Databases, GeneticSystems IntegrationComputational BiologyDrug Resistance, MicrobialGenome, MicrobialHumansInternetMolecular Sequence Annotationantibioticantimicrobial resistance (AMR)genome annotationminimum inhibitory concentrationRASTthe SEED

Identifiers

PMID28968762
PMCPMC6781570

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.