Evidence map›Paper›PMID 28968705›Full record

ArticleBriefings in bioinformatics2019

A comparative study of rank aggregation methods for partial and top ranked lists in genomic applications.

Xue Li, Xinlei Wang, Guanghua Xiao

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Briefings in bioinformatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Statistical genomics in rare cancer.Seminars in cancer biology · 2020
    Pooled it
  4. Journal for immunotherapy of cancer · 2026
    Article
  5. In Silico Selection of GAT-1 Inhibitors.Pharmaceuticals (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xue LiDepartment of Statistical Science at Southern Methodist University, Dallas, TX.
Xinlei WangDepartment of Statistical Science at Southern Methodist University, Dallas, TX.
Guanghua XiaoDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX.

Funding

Integrative Analysis to Identify Therapeutic Targets for Lung CancerR01CA172211 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI XIAO, GUANGHUA · 2013 to 2017
$1.6M
Normalizing Gene Expression Data from Formalin-Fixed Paraffin-Embedded SamplesR15GM131390 · NIGMS · SOUTHERN METHODIST UNIVERSITY · PI WANG, XINLEI · 2019 to 2019
$432k
Wisdom of Crowds: Integrating Gene Set Enrichment Studies Involving RNA-Seq.R15GM113157 · NIGMS · SOUTHERN METHODIST UNIVERSITY · PI WANG, XINLEI · 2015 to 2015
$356k
NCI NIH HHS R01 CA172211NIGMS NIH HHS R15 GM113157NIGMS NIH HHS R15 GM131390
6 · The paper itself

Abstract

Rank aggregation (RA), the process of combining multiple ranked lists into a single ranking, has played an important role in integrating information from individual genomic studies that address the same biological question. In previous research, attention has been focused on aggregating full lists. However, partial and/or top ranked lists are prevalent because of the great heterogeneity of genomic studies and limited resources for follow-up investigation. To be able to handle such lists, some ad hoc adjustments have been suggested in the past, but how RA methods perform on them (after the adjustments) has never been fully evaluated. In this article, a systematic framework is proposed to define different situations that may occur based on the nature of individually ranked lists. A comprehensive simulation study is conducted to examine the performance characteristics of a collection of existing RA methods that are suitable for genomic applications under various settings simulated to mimic practical situations. A non-small cell lung cancer data example is provided for further comparison. Based on our numerical results, general guidelines about which methods perform the best/worst, and under what conditions, are provided. Also, we discuss key factors that substantially affect the performance of the different methods.

Indexed as

Bayes TheoremCarcinoma, Non-Small-Cell LungComputational BiologyComputer SimulationDatabases, GeneticData Interpretation, StatisticalGenomicsHumansLung NeoplasmsMarkov ChainsModels, StatisticalSoftware

Identifiers

PMID28968705
PMCPMC6357556

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.