Evidence map›Paper›PMID 28968669›Full record

ArticleThe Journal of infectious diseases2017

Human Immunodeficiency Virus Type 1 Drug Resistance Mutations Update.

Robert W Shafer

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Mutations in the HIV-1 envelope glycoprotein can broadly rescue blocks at multiple steps in the virus replication cycle.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  7. Article
  8. Article
  9. Emergence of Integrase Resistance Mutations During Initial Therapy Containing Dolutegravir.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Robert W ShaferDivision of Infectious Diseases, Department of Medicine, Stanford University School of Medicine.

Funding

PUBLIC HIV DRUG RESISTANCE DATABASER01AI068581 · NIAID · STANFORD UNIVERSITY · PI SHAFER, ROBERT WILLIAM · 2006 to 2017
$6.2M
NIAID NIH HHS R01 AI068581
6 · The paper itself

Abstract

As treatment options coalesce around a smaller number of antiretroviral drugs (ARVs), data are emerging on the drug resistance mutations (DRMs) selected by the most widely used ARVs and on the impact of these DRMs on ARV susceptibility and virological response to first- and later-line treatment regimens. Recent studies have described the DRMs that emerge in patients receiving tenofovir prodrugs, the nonnucleoside reverse transcriptase inhibitors efavirenz and rilpivirine, ritonavir-boosted lopinavir, and the integrase inhibitors raltegravir and elvitegravir. Several small studies have described DRMs that emerge in patients receiving dolutegravir.

Indexed as

AlkynesAnti-HIV AgentsBenzoxazinesCyclopropanesDolutegravirDrug Resistance, ViralDrug Therapy, CombinationHeterocyclic Compounds, 3-RingHIV-1HumansLopinavirMutationOxazinesPiperazinesPyridonesQuinolonesAlkynesAnti-HIV AgentsBenzoxazinesCyclopropanesDolutegravirefavirenzelvitegravirHeterocyclic Compounds, 3-RingLopinavirOxazinesPiperazinesPyridonesQuinolonesRaltegravir PotassiumRilpivirineTenofovirantiviral drug therapyhuman immunodeficiency virus type 1integraseproteasereverse transcriptase

Identifiers

PMID28968669
PMCPMC5853262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.