Evidence map›Paper›PMID 28968668›Full record

ArticleThe Journal of infectious diseases2017

Rhinovirus Viremia in Patients Hospitalized With Community-Acquired Pneumonia.

Xiaoyan Lu, Eileen Schneider, Seema Jain, Anna M Bramley, Weston Hymas, Chris Stockmann, Krow Ampofo, Sandra R Arnold, Derek J Williams, Wesley H Self and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Rhinovirus Infections and Their Roles in Asthma: Etiology and Exacerbations.The journal of allergy and clinical immunology. In practice · 2022
    Review
  8. Observational
  9. Article
  10. Enhanced Neutralizing Antibody Responses to Rhinovirus C and Age-Dependent Patterns of Infection.American journal of respiratory and critical care medicine · 2021
    Article
  11. Article
  12. Epidemiology and persistence of rhinovirus in pediatric lung transplantation.Transplant infectious disease : an official journal of the Transplantation Society · 2020
    Observational
  13. Article
  14. Article
  15. Review
  16. Observational
  17. Article
  18. Observational
  19. Severe Respiratory Illness Associated With Rhinovirus During the Enterovirus D68 Outbreak in the United States, August 2014-November 2014.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Xiaoyan LuCenters for Disease Control and Prevention.
Eileen SchneiderCenters for Disease Control and Prevention.
Seema JainCenters for Disease Control and Prevention.
Anna M BramleyCenters for Disease Control and Prevention.
Weston HymasUniversity of Utah Health Sciences Center, Salt Lake City.
Chris StockmannUniversity of Utah Health Sciences Center, Salt Lake City.
Krow AmpofoUniversity of Utah Health Sciences Center, Salt Lake City.
Sandra R ArnoldLe Bonheur Children's Hospital, Memphis.
Derek J WilliamsVanderbilt University School of Medicine, Nashville.
Wesley H SelfVanderbilt University School of Medicine, Nashville.
Anami PatelLe Bonheur Children's Hospital, Memphis.
James D ChappellVanderbilt University School of Medicine, Nashville.
Carlos G GrijalvaVanderbilt University School of Medicine, Nashville.
Evan J AndersonEmory University School of Medicine, Atlanta, Georgia.
Richard G WunderinkNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Jonathan A McCullersLe Bonheur Children's Hospital, Memphis.
Kathryn M EdwardsVanderbilt University School of Medicine, Nashville.
Andrew T PaviaUniversity of Utah Health Sciences Center, Salt Lake City.
Dean D ErdmanCenters for Disease Control and Prevention.
Vanderbilt University · USUniversity of Utah · USUniversity of Tennessee Health Science Center · USEmory University · USLe Bonheur Children's Hospital · USNorthwestern University · US

Funding

Development and Validation of a Clinical Prediction Rule for Pediatric PneumoniaK23AI104779 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILLIAMS, DEREK J. · 2013 to 2016
$688k
Intramural CDC HHS CC999999NIAID NIH HHS K23 AI104779
6 · The paper itself

Abstract

Background: Rhinoviruses (RVs) are ubiquitous respiratory pathogens that often cause mild or subclinical infections. Molecular detection of RVs from the upper respiratory tract can be prolonged, complicating etiologic association in persons with severe lower respiratory tract infections. Little is known about RV viremia and its value as a diagnostic indicator in persons hospitalized with community-acquired pneumonia (CAP). Methods: Sera from RV-positive children and adults hospitalized with CAP were tested for RV by real-time reverse-transcription polymerase chain reaction. Rhinovirus species and type were determined by partial genome sequencing. Results: Overall, 57 of 570 (10%) RV-positive patients were viremic, and all were children aged <10 years (n = 57/375; 15.2%). Although RV-A was the most common RV species detected from respiratory specimens (48.8%), almost all viremias were RV-C (98.2%). Viremic patients had fewer codetected pathogens and were more likely to have chest retractions, wheezing, and a history of underlying asthma/reactive airway disease than patients without viremia. Conclusions: More than 1 out of 7 RV-infected children aged <10 years hospitalized with CAP were viremic. In contrast with other RV species, RV-C infections were highly associated with viremia and were usually the only respiratory pathogen identified, suggesting that RV-C viremia may be an important diagnostic indicator in pediatric pneumonia.

Indexed as

AdolescentAdultAgedAged, 80 and overChildChild, PreschoolCommunity-Acquired InfectionsFemaleHumansMaleMiddle AgedPneumonia, ViralReal-Time Polymerase Chain ReactionRhinovirusViremiacommunity-acquired pneumoniarhinovirusviremia

Identifiers

PMID28968668
PMCPMC5724377
OpenAlexW2753587815

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.