Evidence map›Paper›PMID 28968520›Full record

ArticleJournal of inorganic biochemistry2017

Covalent attachment of the heme to Synechococcus hemoglobin alters its reactivity toward nitric oxide.

Matthew R Preimesberger, Eric A Johnson, Dillon B Nye, Juliette T J Lecomte

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Matthew R PreimesbergerT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA.
Eric A JohnsonT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA.
Dillon B NyeT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA.
Juliette T J LecomteT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: lecomte_jtj@jhu.edu.
Johns Hopkins University · US

Funding

PROGRAM IN MOLECULAR BIOPHYSICST32GM008403 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BARRICK, DOUGLAS E. · 1990 to 2019
$13.5M
The Chemistry-Biology Interface Program at Johns Hopkins UniversityT32GM080189 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROKITA, STEVEN E · 2008 to 2022
$3.5M
NIGMS NIH HHS T32 GM008403NIGMS NIH HHS T32 GM080189
6 · The paper itself

Abstract

The cyanobacterium Synechococcus sp. PCC 7002 produces a monomeric hemoglobin (GlbN) implicated in the detoxification of reactive nitrogen and oxygen species. GlbN contains a b heme, which can be modified under certain reducing conditions. The modified protein (GlbN-A) has one heme-histidine C-N linkage similar to the C-S linkage of cytochrome c. No clear functional role has been assigned to this modification. Here, optical absorbance and NMR spectroscopies were used to compare the reactivity of GlbN and GlbN-A toward nitric oxide (NO). Both forms of the protein are capable of NO dioxygenase activity and both undergo heme bleaching after multiple NO challenges. GlbN and GlbN-A bind NO in the ferric state and form diamagnetic complexes (Fe

Indexed as

Bacterial ProteinsHemeLigandsMagnetic Resonance SpectroscopyNitric OxideNitrogen OxidesOxidation-ReductionOxidoreductasesOxygenOxygenasesProtein Processing, Post-TranslationalSynechococcusSynechocystisTruncated HemoglobinsBacterial ProteinsHemeLigandsNitric Oxidenitric oxide dioxygenasenitric-oxide reductaseNitrogen OxidesnitroxylOxidoreductasesOxygenOxygenasesTruncated HemoglobinsNitric oxide dioxygenaseNitric oxide reductaseNitrite reductaseNitrosyl hydrideNitroxylTruncated hemoglobin

Identifiers

PMID28968520
PMCPMC6214621
OpenAlexW2758107652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.