ArticlePLoS computational biology2017
A continuum-mechanical skeletal muscle model including actin-titin interaction predicts stable contractions on the descending limb of the force-length relation.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Theoretical analysis of power-law stress relaxation and calcium-dependent passive mechanics in cardiac muscle.The Journal of physiology · 2025Article
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- Eccentric muscle contractions: from single muscle fibre to whole muscle mechanics.Pflugers Archiv : European journal of physiology · 2023Review
- Modelling motor units in 3D: influence on muscle contraction and joint force via a proof of concept simulation.Biomechanics and modeling in mechanobiology · 2023Article
- Ultrastructural and kinetic evidence support that thick filaments slide through the Z-disc.Journal of the Royal Society, Interface · 2022Article
- Multi-scale mechanobiological model for skeletal muscle hypertrophy.Frontiers in physiology · 2022Article
- Power Amplification Increases With Contraction Velocity During Stretch-Shortening Cycles of Skinned Muscle Fibers.Frontiers in physiology · 2021Article
- Non-cross Bridge Viscoelastic Elements Contribute to Muscle Force and Work During Stretch-Shortening Cycles: Evidence From Whole Muscles and Permeabilized Fibers.Frontiers in physiology · 2021Article
- A Physiology-Guided Classification of Active-Stress and Active-Strain Approaches for Continuum-Mechanical Modeling of Skeletal Muscle Tissue.Frontiers in physiology · 2021Article
- Biarticular muscles in light of template models, experiments and robotics: a review.Journal of the Royal Society, Interface · 2020Review
- Microstructural analysis of skeletal muscle force generation during aging.International journal for numerical methods in biomedical engineering · 2020Article
- Extensive eccentric contractions in intact cardiac trabeculae: revealing compelling differences in contractile behaviour compared to skeletal muscles.Proceedings. Biological sciences · 2019Article
- Characterization of Electromechanical Delay Based on a Biophysical Multi-Scale Skeletal Muscle Model.Frontiers in physiology · 2019Article
- Enabling Detailed, Biophysics-Based Skeletal Muscle Models on HPC Systems.Frontiers in physiology · 2018Article
- An Efficient Modelling-Simulation-Analysis Workflow to Investigate Stump-Socket Interaction Using Patient-Specific, Three-Dimensional, Continuum-Mechanical, Finite Element Residual Limb Models.Frontiers in bioengineering and biotechnology · 2018Article
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5 authors.
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Abstract
Contractions on the descending limb of the total (active + passive) muscle force-length relationship (i. e. when muscle stiffness is negative) are expected to lead to vast half-sarcomere-length inhomogeneities. This is however not observed in experiments-vast half-sarcomere-length inhomogeneities can be absent in myofibrils contracting in this range, and initial inhomogeneities can even decrease. Here we show that the absence of half-sarcomere-length inhomogeneities can be predicted when considering interactions of the semi-active protein titin with the actin filaments. Including a model of actin-titin interactions within a multi-scale continuum-mechanical model, we demonstrate that stability, accurate forces and nearly homogeneous half-sarcomere lengths can be obtained on the descending limb of the static total force-length relation. This could be a key to durable functioning of the muscle because large local stretches, that might harm, for example, the transverse-tubule system, are avoided.
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