Evidence map›Paper›PMID 28968244›Full record

SynthesisJournal of Huntington's disease2017

Physical Therapy and Exercise Interventions in Huntington's Disease: A Mixed Methods Systematic Review.

Nora E Fritz, Ashwini K Rao, Deb Kegelmeyer, Anne Kloos, Monica Busse, Lynda Hartel, Judith Carrier, Lori Quinn

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of Huntington's disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 6 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 6 syntheses or guidelines pooled it, 101 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Nora E FritzProgram in Physical Therapy, Wayne State University, Detroit, MI, USA.
Ashwini K RaoProgram in Physical Therapy, Department of Rehabilitative and Regenerative Medicine, Columbia University, New York, NY, USA.
Deb KegelmeyerPhysical Therapy Division, School of Health and Rehabilitation Sciences, Ohio State University, Columbus, USA.
Anne KloosPhysical Therapy Division, School of Health and Rehabilitation Sciences, Ohio State University, Columbus, USA.
Monica BusseCentre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.
Lynda HartelHealth Sciences Library, The Ohio State University, Columbus, OH, USA.
Judith CarrierThe Wales Centre for Evidence-Based Care, a Joanna Briggs Institute Centre of Excellence, School of Healthcare Sciences, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.
Lori QuinnDepartment of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY, USA.
Cardiff University · GBColumbia University · USThe Ohio State University · USState Library of Ohio · USWayne State University · US

Funding

HCRW_ NIHR-FS-2012
6 · The paper itself

Abstract

backgroundA number of studies evaluating physical therapy and exercise interventions in Huntington's disease have been conducted over the past 15 years. However, an assessment of the quality and strength of the evidence in support of these interventions is lacking.

objectiveThe purpose of this systematic review was to investigate the effectiveness of physical therapy and exercise interventions in people with Huntington's disease, and to examine the perceptions of patients, families and caregivers of these interventions.

methodsThis mixed-methods systematic review utilized the Joanna Briggs Institute (JBI) approach and extraction tools to evaluate the literature from January 2003 until May 2016. The review considered interventions that included exercise and physical therapy interventions, and included both quantitative and qualitative outcome measures.

resultsTwenty (20) studies met the inclusion criteria, including eighteen (18) that had quantitative outcome measures and two (2) that utilized qualitative methods. JBI Levels of evidence for the 18 quantitative studies were as follows: Eight studies were at evidence Level 1, seven were at Level 2, two were at Level 3, and one was at Level 4.

conclusionsOur review suggests that there is preliminary support for the benefits of exercise and physical activity in Huntington's disease in terms of motor function, gait speed, and balance, as well as a range of physical and social benefits identified through patient-reported outcomes. Variability in mode of intervention as well as outcome measures limits the interpretability of these studies, and high-quality studies that incorporate adaptive trial designs for this rare disease are needed.

Indexed as

Physical Therapy ModalitiesExercise TherapyFemaleHumansHuntington DiseaseMaleOutcome Assessment, Health CareclassificationsexerciseHuntington’s diseasemovement systemphysical activityphysical therapyphysiotherapy

Identifiers

PMID28968244
PMCPMC5676854
OpenAlexW2612647959

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.