Evidence map›Paper›PMID 28968196›Full record

ArticleZebrafish2017

Report of Workshop on Euthanasia for Zebrafish-A Matter of Welfare and Science.

Almut Köhler, Chereen Collymore, Karin Finger-Baier, Robert Geisler, Larissa Kaufmann, Kieran C Pounder, Stefan Schulte-Merker, Ana Valentim, Zoltan M Varga, Jürgen Weiss and 1 more

Abstract readConference Proceedings
In one paragraph

Article in Zebrafish, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Zebrafish: A Versatile and Powerful Model for Biomedical Research.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Almut Köhler1 Safety and Environment, Karlsruhe Institute of Technology (KIT) , Karlsruhe, Germany .
Chereen Collymore2 Division of Comparative Medicine, University of Toronto , Toronto, Canada .
Karin Finger-Baier3 Department of Genes-Circuits-Behavior, Max Planck Institute of Neurobiology , Martinsried, Germany .
Robert Geisler4 European Zebrafish Resource Center, Karlsruhe Institute of Technology (KIT) , Karlsruhe, Germany .
Larissa Kaufmann5 European Society for Fish Models in Biology and Medicine, Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT) , Karlsruhe, Germany .
Kieran C Pounder6 Institute of Integrative Biology, University of Liverpool , Liverpool, United Kingdom .
Stefan Schulte-Merker7 Faculty of Medicine, Institute for Cardiovascular Organogenesis and Regeneration, University of Münster , Münster, Germany .
Ana Valentim8 i3S-Instituto de Investigação e Inovação em Saúde and IBMC-Instituto de Biologia Molecular e Celular , Universidade do Porto, Porto, Portugal .
Zoltan M Varga10 Zebrafish International Resource Center, Institute of Neuroscience, University of Oregon , Eugene, Oregon.
Jürgen Weiss11 Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT) , Karlsruhe, Germany .
Uwe Strähle5 European Society for Fish Models in Biology and Medicine, Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT) , Karlsruhe, Germany .

Funding

Zebrafish International Resource Center (ZIRC)P40OD011021 · OD · UNIVERSITY OF OREGON · PI Zoltan Marton Varga · 2012 to 2026
$36.0M
NIH HHS P40 OD011021
6 · The paper itself

Abstract

The increasing importance of zebrafish as a biomedical model organism is reflected by the steadily growing number of publications and laboratories working with this species. Regulatory recommendations for euthanasia as issued in Directive 2010/63/EU are, however, based on experience with fish species used for food production and do not take the small size and specific physiology of zebrafish into account. Consequently, the currently recommended methods of euthanasia in the Directive 2010/63/EU are either not applicable or may interfere with research goals. An international workshop was held in Karlsruhe, Germany, March 9, 2017, to discuss and propose alternative methods for euthanasia of zebrafish. The aim was to identify methods that adequately address the physiology of zebrafish and its use as a biomedical research model, follow the principles of the 3Rs (Replacement, Reduction, and Refinement) in animal experimentation and consider animal welfare during anesthesia and euthanasia. The results of the workshop are summarized here in the form of a white paper.

Indexed as

Animal WelfareEuthanasia, AnimalAnesthesiaAnimalsLaboratory Animal ScienceZebrafishanestheticsDirective 2010/63/EUeuthanasiahypothermic shockrapid coolingzebrafish

Identifiers

PMID28968196
PMCPMC5706616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.