ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2018
Examination of the role of obesity in the association between childhood trauma and inflammation during pregnancy.
Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Inflammatory Stress Response During Pregnancy as a Connecting Link in Intergenerational Risk Cascades.Developmental psychobiology · 2026Article
- Maternal adversity and peripheral proinflammatory cytokine concentrations in pregnancy.Brain, behavior, & immunity - health · 2026Article
- Beyond Psychological Trauma: Associations of Nutritional Status with Depression in Child and Adolescent Victims of Crime.Healthcare (Basel, Switzerland) · 2026Article
- A Brief Historic Review of Research on Early Life Stress and Inflammation across the Lifespan.Neuroimmunomodulation · 2025Review
- Estimating the associations between women's maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy.PloS one · 2025Article
- Inflammatory burden of adolescents with childhood maltreatment: results from baseline data of a school cohort.European child & adolescent psychiatry · 2024Article
- Cumulative maternal lifetime stress & child asthma: effect modification by BMI.Stress (Amsterdam, Netherlands) · 2024Article
- Maternal exposure to childhood maltreatment and adverse birth outcomes.Scientific reports · 2023Article
- Maternal early life stress is associated with pro-inflammatory processes during pregnancy.Brain, behavior, and immunity · 2023Article
- IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies.International journal of molecular sciences · 2022Review
- Childhood adversity, prenatal depression, and maternal inflammation across pregnancy.Obstetric medicine · 2022Article
- Exposure to childhood maltreatment and systemic inflammation across pregnancy: The moderating role of depressive symptomatology.Brain, behavior, and immunity · 2022Article
- Stress-Related Mental Health Disorders and Inflammation in Pregnancy: The Current Landscape and the Need for Further Investigation.Frontiers in psychiatry · 2022Review
- Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia.Journal of pregnancy · 2021Review
- Elevated pro-inflammatory gene expression in the third trimester of pregnancy in mothers who experienced stressful life events.Brain, behavior, and immunity · 2019Article
- Innate immune activation and depressive and anxious symptoms across the peripartum: An exploratory study.Psychoneuroendocrinology · 2019Article
- Pathways linking childhood abuse history and current socioeconomic status to inflammation during pregnancy.Brain, behavior, and immunity · 2018Article
- Co-occurrence of preconception maternal childhood adversity and opioid use during pregnancy: Implications for offspring brain development.Neurotoxicology and teratologyArticle
- Psychological Stress During Childhood and Adolescence and Its Association With Inflammation Across the Lifespan: A Critical Review and Meta-Analysis.Psychological bulletinArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveChildhood trauma is associated with negative perinatal health outcomes including mood disorders and shorter gestation. However, effects of early life exposures on maternal biology are poorly delineated. This study examined associations between childhood trauma and inflammation, as well as the mediating role of obesity in this relationship.
methodThis study examined a racially diverse sample of 77 pregnant women assessed in early, mid, and late pregnancy. Assessments included the Childhood Trauma Questionnaire, Center for Epidemiologic Studies-Depression Scale, serum CRP, IL-6, and TNF-α, and prepregnancy BMI.
resultsPer linear mixed models, while no direct relationships were observed between childhood trauma with IL-6 or TNF-α, physical (95% CI: 0.007, 0.080) and emotional (95% CI: 0.005, 0.046) abuse as well as emotional neglect (95% CI: 0.010, 0.051) predicted elevated CRP. Effects remained after adjustment for race, income, education, smoking status, medical conditions, and depressive symptoms. PROCESS analyses showed BMI mediated the relationship between physical abuse and both serum CRP (95% CI: 0.014, 0.062) and IL-6 (95% CI: 0.009, 0.034).
conclusionsExposure to childhood trauma, particularly emotional abuse, physical abuse, and emotional neglect, is associated with inflammation in pregnant women. Obesity served as 1 pathway by which physical abuse contributed to elevations in serum CRP and IL-6. Interventions targeting maternal obesity prior to pregnancy may help mitigate the effects of childhood trauma on perinatal health. These findings have relevance for understanding biological and behavioral pathways by which early life exposures contribute to maternal health. (PsycINFO Database Record
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