ArticleESC heart failure2018
The association between high-dose loop diuretic use at discharge and cardiovascular mortality in patients with heart failure.
Article in ESC heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Association of loop diuretics use and dose with outcomes in outpatients with heart failure: a systematic review and meta-analysis of observational studies involving 96,959 patients.Heart failure reviews · 2022Pooled it
- Optimal surgical timing for atrial functional mitral regurgitation based on preoperative diuretic requirement: a retrospective cohort study.Journal of thoracic disease · 2026Article
- Economic Evaluation of Patiromer in Patients with Concomitant Heart Failure and Chronic Kidney Disease in Italy.PharmacoEconomics - open · 2025Article
- Prognostic implication of outpatient loop diuretic dose intensification trajectories in patients with chronic heart failure.International journal of cardiology. Heart & vasculature · 2025Article
- Observational
- Prognostic impact of outpatient loop diuretic reduction patterns in patients with chronic heart failure.International journal of cardiology. Heart & vasculature · 2024Article
- Prognostic impact of MitraScore in elderly Asian patients with heart failure: sub-analysis of FRAGILE-HF.ESC heart failure · 2024Article
- Association between changes in loop diuretic dose and outcomes in acute heart failure.ESC heart failure · 2023Article
- Association of Potassium Level at Discharge with Long-Term Mortality in Hospitalized Patients with Heart Failure.Journal of clinical medicine · 2022Article
- Clinical relevance of serum electrolytes in dogs and cats with acute heart failure: A retrospective study.Journal of veterinary internal medicine · 2021Article
- Temporal trends of a vasopressin VESC heart failure · 2021Article
- Impact of acute kidney injury on prognosis and the effect of tolvaptan in patients with hepatic ascites.Journal of gastroenterology · 2021Article
- Poor prognosis of heart failure patients with in-hospital worsening renal function and elevated BNP at discharge.ESC heart failure · 2020Article
- Heart Failure Drug Class Effects on 30-Day Readmission Rates in Patients with Heart Failure with Preserved Ejection Fraction: A Retrospective Single Center Study.Medicines (Basel, Switzerland) · 2020Article
- New treatments for hyperkalaemia: clinical use in cardiology.European heart journal supplements : journal of the European Society of Cardiology · 2019Article
- Diuretic dosing in heart failure: more data are needed.ESC heart failure · 2018Article
- The association between high-dose loop diuretic use at discharge and cardiovascular mortality in patients with heart failure.ESC heart failure · 2018Article
Corrections and comments
- Commented on by
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsFew studies have reported the impact of high-dose loop diuretics at discharge on prognosis in Japanese patients with heart failure (HF). Our purpose was to assess the relationship between the dose of loop diuretics at discharge and cardiovascular mortality in patients with HF. METHODS AND
resultsWe enrolled decompensated HF patients who were admitted to our hospital between March 2010 and March 2015, and compared HF patients who received high-dose loop diuretics at discharge (HD group) with low-dose loop diuretics at discharge (LD group) with regard to risk of cardiovascular mortality, and all-cause mortality. High-dose loop diuretic was defined as ≥40 mg/day of oral furosemide at discharge. A total of 215 patients were enrolled to the study. The median follow-up duration was 641 days. All-cause and cardiovascular mortality were significantly lower in the LD group than in the HD group (10.4% vs. 31.6%, P < 0.001; 2.2% vs. 24.6%, P < 0.001, respectively). High-dose loop diuretics were associated with cardiovascular mortality in multivariate Cox proportional hazards model (hazard ratio, 16.06, 95% confidence interval 3.457 to 116.8; P < 0.001). The largest area under the receiver operating characteristic curve (0.85) for cardiovascular death was obtained with a threshold of 40 mg furosemide.
conclusionsHigh-dose loop diuretic use at discharge was one of the predictors of cardiovascular mortality in patients with HF. An oral furosemide dose of 40 mg daily may be defined as 'high-dose' loop diuretics in Japanese patients with chronic HF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.