ReviewBiological psychiatry2018
Structural Neuroimaging of Anorexia Nervosa: Future Directions in the Quest for Mechanisms Underlying Dynamic Alterations.
Review in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 5 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Cortical complexity in eating disorders: a systematic review and qualitative synthesis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group.Biological psychiatry · 2022Pooled it
- The role of prenatal and perinatal factors in eating disorders: a systematic review.Archives of women's mental health · 2021Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Altered thalamo–cortical and occipital–parietal– temporal–frontal white matter connections in patients with anorexia and bulimia nervosa: a systematic review of diffusion tensor imaging studiesJournal of psychiatry & neuroscience : JPN · 2019Pooled it
- Brain Connectivity and Machine Learning Approaches to assess the underlying neurobiology and prediction accuracy of anorexia nervosa: A replication study.Psychiatry research. Neuroimaging · 2026Article
- Nutritional state-dependent changes in subcortical limbic structures in anorexia nervosa are linked to leptin, ghrelin, and neurofilament light.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Fasting gut hormone levels following long-term recovery from Anorexia Nervosa: A cross-sectional study.Journal of eating disorders · 2026Article
- Dynamic white matter microstructure in anorexia nervosa: associations with neurofilament light and leptin across early weight restoration.Research square · 2026Article
- Elevated neurofilament light levels in acute anorexia nervosa are associated with alterations in white matter volume and connectivity networks.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- A person-centred and data-driven approach to phenotyping anorexia nervosa.Journal of eating disorders · 2026Article
- Brain morphology in Anorexia Nervosa and its subtypes: A multi-cohort study of individual participant data.PLoS medicine · 2026Article
- Annual Research Review: Neural mechanisms of eating disorders in youth - from current theory and findings to future directions.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Eating and Mental Health Disorders.Nutrients · 2026Article
- Mapping the path to recovery: the intersection of cortical thickness reductions and serotonin transporter expression in anorexia nervosa.Molecular psychiatry · 2026Article
- The Possible Role of Neurofilament Light Chain as a Serum Biomarker in Anorexia Nervosa: Clinical Implications.Biomolecules · 2025Article
- Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.Molecular psychiatry · 2025Article
- Body Mass Index Impacts on Gray Matter Volume in Developmental Restrictive Anorexia Nervosa: A Voxel-Based Morphometry Study.Nutrients · 2025Article
- Does restrictive anorexia nervosa impact brain aging? A machine learning approach to estimate age based on brain structure.Computers in biology and medicine · 2025Article
- Structural connectome manifold changes related to body mass index and their associations with eating psychopathology.NeuroImage. Clinical · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Anorexia nervosa (AN) is a serious eating disorder characterized by self-starvation and extreme weight loss. Pseudoatrophic brain changes are often readily visible in individual brain scans, and AN may be a valuable model disorder to study structural neuroplasticity. Structural magnetic resonance imaging studies have found reduced gray matter volume and cortical thinning in acutely underweight patients to normalize following successful treatment. However, some well-controlled studies have found regionally greater gray matter and persistence of structural alterations following long-term recovery. Findings from diffusion tensor imaging studies of white matter integrity and connectivity are also inconsistent. Furthermore, despite the severity of AN, the number of existing structural neuroimaging studies is still relatively low, and our knowledge of the underlying cellular and molecular mechanisms for macrostructural brain changes is rudimentary. We critically review the current state of structural neuroimaging in AN and discuss the potential neurobiological basis of structural brain alterations in the disorder, highlighting impediments to progress, recent developments, and promising future directions. In particular, we argue for the utility of more standardized data collection, adopting a connectomics approach to understanding brain network architecture, employing advanced magnetic resonance imaging methods that quantify biomarkers of brain tissue microstructure, integrating data from multiple imaging modalities, strategic longitudinal observation during weight restoration, and large-scale data pooling. Our overarching objective is to motivate carefully controlled research of brain structure in eating disorders, which will ultimately help predict therapeutic response and improve treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.