Evidence map›Paper›PMID 28967294›Full record

Trial reportJournal of neurotrauma2018

An Autonomic Neuroprosthesis: Noninvasive Electrical Spinal Cord Stimulation Restores Autonomic Cardiovascular Function in Individuals with Spinal Cord Injury.

Aaron A Phillips, Jordan W Squair, Dimitry G Sayenko, V Reggie Edgerton, Yury Gerasimenko, Andrei V Krassioukov

4 registry-linked trialsOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurotrauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 74 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03924388 naunknown statusnot on this mapstarted 2020, after this paper: background citation

The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury

TypeinterventionalSponsorUniversity of CalgaryRan2020 to 2022Enrolled46ConditionsSpinal Cord Injuries, Autonomic Dysreflexia, Orthostatic Hypotension, DysautonomicArmsEpidural spinal cord stimulation, Trnascutaneous electrical spinal cord stimulation.
NCT05111093 narecruitingnot on this mapstarted 2021, after this paper: background citation

Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury

TypeinterventionalSponsorEcole Polytechnique Fédérale de LausanneRan2021 to 2030Enrolled20ConditionsSpinal Cord InjuriesArmsARC-IM Investigational System implantation
NCT05230147 nacompletednot on this mapstarted 2022, after this paper: background citation

Hemodynamic Effects of Transcutaneous Spinal Cord Stimulation During Passive Orthostasis: a Prospective Single-center Randomized Cross-over Study

TypeinterventionalSponsorFederal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of HealthRan2022 to 2024Enrolled20ConditionsOrthostatic HypotensionArmsSpinal cord stimulation, Sham stimulation
NCT06587841 narecruitingnot on this mapstarted 2024, after this paper: background citation

Noninvasive Spinal Cord Neuromodulation to Improve Lower Urinary Tract Function After Spinal Cord Injury in Ukrainian War Veterans

TypeinterventionalSponsorUniversity of British ColumbiaRan2024 to 2027Enrolled60ConditionsSpinal Cord Injuries, Bowel Dysfunction, Sexual Dysfunction, Autonomic DysfunctionArmsSpinal COrd NEuromodulation™ (SCONE™) for transcutaneous spinal cord stimulation (TSCS)
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Cardiovascular safety of transcutaneous spinal cord stimulation in cervical spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  19. Review
  20. Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aaron A Phillips1 ICORD-BSCC, University of British Columbia , Vancouver, British Columbia, Canada .
Jordan W Squair1 ICORD-BSCC, University of British Columbia , Vancouver, British Columbia, Canada .
Dimitry G Sayenko2 Department of Integrative Biology and Physiology, University of California , Los Angeles, Los Angeles, California.
V Reggie Edgerton2 Department of Integrative Biology and Physiology, University of California , Los Angeles, Los Angeles, California.
Yury Gerasimenko2 Department of Integrative Biology and Physiology, University of California , Los Angeles, Los Angeles, California.
Andrei V Krassioukov1 ICORD-BSCC, University of British Columbia , Vancouver, British Columbia, Canada .
University of California, Los Angeles · US

Funding

Enabling forelimb function with agonist drug and epidural stimulation in SCIU01EB015521 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE, LU, DANIEL · 2013 to 2017
$6.0M
Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCIR01EB007615 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE · 2008 to 2013
$4.9M
NIBIB NIH HHS R01 EB007615NIBIB NIH HHS U01 EB015521
6 · The paper itself

Abstract

Despite autonomic dysfunction after spinal cord injury (SCI) being the major cause of death and a top health priority, the clinical management options for these conditions are limited to drugs with delayed onset and nonpharmacological interventions with equivocal effectiveness. We tested the capacity of electrical stimulation, applied transcutaneously over the spinal cord, to manage autonomic dysfunction in the form of orthostatic hypotension after SCI. We assessed beat-by-beat blood pressure (BP), stroke volume, and cardiac contractility (dP/dt; Finometer), as well as cerebral blood flow (transcranial Doppler) in 5 individuals with motor-complete SCI (4 cervical, 1 thoracic) during an orthostatic challenge with and without transcutaneous electrical stimulation applied at the TVII level. During the orthostatic challenge, all individuals experienced hypotension characterized by a 37 ± 4 mm Hg decrease in systolic BP, a 52 ± 10% reduction in cardiac contractility, and a 23 ± 6% reduction in cerebral blood flow (all p < 0.05), along with severe self-reported symptoms. Electrical stimulation completely normalized BP, cardiac contractility, cerebral blood flow, and abrogated all symptoms. Noninvasive transcutaneous electrical spinal cord stimulation may be a viable therapy for restoring autonomic cardiovascular control after SCI.

Indexed as

AdultAutonomic Nervous SystemCardiovascular SystemCervical CordHumansHypotension, OrthostaticSpinal Cord InjuriesSpinal Cord StimulationYoung Adultautonomiccardiovascularneurological injuryspinal cordspinal cord injurystimulation

Identifiers

PMID28967294
PMCPMC5793952
OpenAlexW2761453644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.