Evidence map›Paper›PMID 28967282›Full record

ArticleBrain connectivity2017

Resting State Functional Connectivity Signature of Treatment Effects of Repetitive Transcranial Magnetic Stimulation in Mal de Debarquement Syndrome.

Han Yuan, Guofa Shou, Diamond Gleghorn, Lei Ding, Yoon-Hee Cha

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain connectivity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Transcranial Alternating Current Stimulation Reduces Network Hypersynchrony and Persistent Vertigo.Neuromodulation : journal of the International Neuromodulation Society · 2021
    Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Transcranial Magnetic Stimulation as Treatment for Mal de Debarquement Syndrome: Case Report and Literature Review.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2020
    Article
  12. Article
  13. Occipital and Cerebellar Theta Burst Stimulation for Mal De Debarquement Syndrome.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2019
    Article
  14. Article
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  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Han Yuan1 Stephenson School of Biomedical Engineering, University of Oklahoma , Norman, Oklahoma.
Guofa Shou1 Stephenson School of Biomedical Engineering, University of Oklahoma , Norman, Oklahoma.
Diamond Gleghorn2 Laureate Institute for Brain Research , Tulsa, Oklahoma.
Lei Ding1 Stephenson School of Biomedical Engineering, University of Oklahoma , Norman, Oklahoma.
Yoon-Hee Cha2 Laureate Institute for Brain Research , Tulsa, Oklahoma.
Laureate Institute for Brain Research · USUniversity of Oklahoma · US

Funding

Functional Neuroimaging and Transcranial Magnetic Stimulation in Mal de DebarquemR03DC010451 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHA, YOON-HEE K · 2010 to 2012
$452k
NIDCD NIH HHS R03 DC010451
6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) has been used in experimental protocols to treat mal de debarquement syndrome (MdDS), a neurological condition that represents a maladaptive brain state resulting from entrainment to external oscillating motion. Medical treatments and biomarkers for MdDS remain limited but neuromodulation with rTMS has shown evidence for therapeutic effects. This study took a neuroimaging approach to examine the neuromodulatory effect of rTMS on MdDS. Twenty individuals with MdDS underwent five daily treatments of rTMS over bilateral dorsolateral prefrontal cortex (DLPFC). Participants received 1 Hz over right DLPFC (1200 pulses) followed by 10 Hz over left DLPFC (2000 pulses). Resting state functional magnetic resonance imaging was acquired before and after treatments to determine functional connectivity changes associated with a positive treatment effect. A single-subject-based analysis protocol was developed to capture the degree of resting state functional connectivity (RSFC) between the rTMS target and the entorhinal cortex (EC), an area previously shown to be hypermetabolic in MdDS. Our results showed that rocking motion perception in subjects was modulated by rTMS over the DLPFC. Improvements in symptoms correlated most strongly with a post-rTMS reduction in functional connectivity between the left EC and the precuneus, right inferior parietal lobule, and the contralateral EC, which are part of the posterior default mode network. Positive response to rTMS correlated with higher baseline RSFC between the DLPFC and the EC. Our findings suggest that baseline prefrontal-limbic functional connectivity may serve as a predictor of treatment response to prefrontal stimulation in MdDS and that RSFC may serve as a dynamic biomarker of symptom status.

Indexed as

RestTravelAdultAgedFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMotion SicknessNeural PathwaysOxygenPrefrontal CortexTranscranial Magnetic StimulationTravel-Related IllnessOxygenBOLD fMRIdorsolateral prefrontal cortexresting state functional connectivitytranscranial magnetic stimulation

Identifiers

PMID28967282
PMCPMC5695731
OpenAlexW2763485123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.