Evidence map›Paper›PMID 28967180›Full record

ReviewPest management science2018

RNAi as an emerging approach to control Fusarium head blight disease and mycotoxin contamination in cereals.

Ana Karla Machado, Neil A Brown, Martin Urban, Kostya Kanyuka, Kim E Hammond-Kosack

Open access · hybridAbstract readReview
In one paragraph

Review in Pest management science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
24.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 116 citations in OpenAlex.

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  13. Impact ofJournal of fungi (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ana Karla MachadoDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden, UK.
Neil A BrownDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden, UK.
Martin UrbanDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden, UK.
Kostya KanyukaDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden, UK.
Kim E Hammond-KosackDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden, UK.ORCID http://orcid.org/0000-0002-9699-485X
Rothamsted Research · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fusarium graminearum is a major fungal pathogen of cereals worldwide, causing seedling, stem base and floral diseases, including Fusarium head blight (FHB). In addition to yield and quality losses, FHB contaminates cereal grain with mycotoxins, including deoxynivalenol, which are harmful to human, animal and ecosystem health. Currently, FHB control is only partially effective due to several intractable problems. RNA interference (RNAi) is a natural mechanism that regulates gene expression. RNAi has been exploited in the development of new genomic tools that allow the targeted silencing of genes of interest in many eukaryotes. Host-induced gene silencing (HIGS) is a transgenic technology used to silence fungal genes in planta during attempted infection and thereby reduces disease levels. HIGS relies on the host plant's ability to produce mobile small interfering RNA molecules, generated from long double-stranded RNA, which are complementary to targeted fungal genes. These molecules are transferred from the plant to invading fungi via an uncharacterised mechanism, to cause gene silencing. Here, we describe recent advances in RNAi-mediated control of plant pathogenic fungi, highlighting the key advantages and disadvantages. We then discuss the developments and implications of combining HIGS with other methods of disease control. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

RNA InterferenceEdible GrainFusariumGenes, FungalMycotoxinsPlant DiseasesMycotoxinsbarleydeoxynivalenoldisease resistancefungal diseasesFusarium graminearumhost-induced gene silencing (HIGS)maizespray-induced gene silencing (SIGS)transgenic plantswheat

Identifiers

PMID28967180
PMCPMC5873435
OpenAlexW2763198345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.