Evidence map›Paper›PMID 28967047›Full record

ArticleJournal of molecular neuroscience : MN2017

Expression Analysis of Long Non-coding RNAs in the Blood of Multiple Sclerosis Patients.

Mohammad Mahdi Eftekharian, Soudeh Ghafouri-Fard, Mohammad Soudyab, Mir Davood Omrani, Mahnoosh Rahimi, Arezou Sayad, Alireza Komaki, Mehrdokht Mazdeh, Mohammad Taheri

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Article in Journal of molecular neuroscience : MN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mohammad Mahdi EftekharianNeurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Soudeh Ghafouri-FardDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad SoudyabDepartment of Medical Genetics, Mashhad University of Medical Sciences, Mashhad, Iran.
Mir Davood OmraniDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahnoosh RahimiDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arezou SayadDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Alireza KomakiNeurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Mehrdokht MazdehDepartment of Neurology, Hamedan University of Medical Sciences, Hamadan, Iran.
Mohammad TaheriDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. mohammad_823@yahoo.com.ORCID http://orcid.org/0000-0001-8381-0591
Shahid Beheshti University of Medical Sciences · IRHamedan University of Medical Sciences · IRMashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic immune-mediated disorder of the central nervous system (CNS) with multiple genetic and environmental risk factors. Long non-coding RNAs (lncRNAs) have been recently reported to participate in the regulation of immune responses. Consequently, aberrant expression of lncRNAs has been suggested as an underlying cause of MS. In the present study, we evaluated the expression of three lncRNAs with putative roles in the regulation of immune response, namely TNF-α and heterogeneous nuclear ribonucleoprotein L (THRIL), Fas cell surface death receptor- antisense 1 (FAS-AS1), and plasmacytoma variant translocation 1 (PVT1) in circulating blood cells of 50 Iranian relapsing-remitting multiple sclerosis (RRMS) patients compared with healthy subjects by means of quantitative real-time polymerase chain reaction (PCR). We detected a significant downregulation of PVT1 and FAS-AS1 expressions in RRMS patients while a significant upregulation of THRIL in patients compared with controls (P < 0.001). Correlation analyses between lncRNA expression levels and clinical data of MS patients revealed no significant correlation between lncRNAs expression levels and Expanded Disability Status Scale (EDSS), a moderate correlation between PVT1 expression levels and duration of the disorder and no significant correlation between lncRNAs expression levels and age at onset. In addition, we demonstrated correlations between the expression levels of PVT1 and THRIL as well as expression levels of THRIL and FAS-AS1 in RRMS patients. In brief, we have demonstrated dysregulation of three lncRNAs in MS patients. Further studies are needed to explore the exact mechanisms by which these lncRNAs participate in regulation of immune responses.

Indexed as

AdultBiomarkersCase-Control StudiesFemaleHumansMaleMultiple Sclerosis, Relapsing-RemittingRNA, Long NoncodingBiomarkersRNA, Long NoncodingFAS-AS1lncRNAMultiple sclerosisPVT1THRIL

Identifiers

PMID28967047
OpenAlexW2757426058

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.