Evidence map›Paper›PMID 28966872›Full record

ArticleNature biomedical engineering2017

Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes.

Yuan Wan, Gong Cheng, Xin Liu, Si-Jie Hao, Merisa Nisic, Chuan-Dong Zhu, Yi-Qiu Xia, Wen-Qing Li, Zhi-Gang Wang, Wen-Long Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biomedical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed.

  1. Article
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  15. Developing Biomaterial-Based mRNA Delivery System for Lung Disease Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuan WanDepartment of Biomedical Engineering, Micro & Nano Integrated Biosystem (MINIBio) Laboratory, The Pennsylvania State University, University Park, PA 16802, U.S.A.
Gong ChengDepartment of Biomedical Engineering, Micro & Nano Integrated Biosystem (MINIBio) Laboratory, The Pennsylvania State University, University Park, PA 16802, U.S.A.
Xin LiuPenn State Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033, U.S.A.
Si-Jie HaoDepartment of Biomedical Engineering, Micro & Nano Integrated Biosystem (MINIBio) Laboratory, The Pennsylvania State University, University Park, PA 16802, U.S.A.
Merisa NisicDepartment of Biomedical Engineering, Micro & Nano Integrated Biosystem (MINIBio) Laboratory, The Pennsylvania State University, University Park, PA 16802, U.S.A.
Chuan-Dong ZhuDepartment of Biomedical Engineering, Micro & Nano Integrated Biosystem (MINIBio) Laboratory, The Pennsylvania State University, University Park, PA 16802, U.S.A.
Yi-Qiu XiaDepartment of Biomedical Engineering, Micro & Nano Integrated Biosystem (MINIBio) Laboratory, The Pennsylvania State University, University Park, PA 16802, U.S.A.
Wen-Qing LiDepartment of Biomedical Engineering, Micro & Nano Integrated Biosystem (MINIBio) Laboratory, The Pennsylvania State University, University Park, PA 16802, U.S.A.
Zhi-Gang WangDepartment of Biomedical Engineering, Micro & Nano Integrated Biosystem (MINIBio) Laboratory, The Pennsylvania State University, University Park, PA 16802, U.S.A.
Wen-Long ZhangDepartment of Biomedical Engineering, Micro & Nano Integrated Biosystem (MINIBio) Laboratory, The Pennsylvania State University, University Park, PA 16802, U.S.A.
Shawn J RicePenn State Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033, U.S.A.
Aswathy SebastianDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, U.S.A.
Istvan AlbertThe Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, U.S.A.
Chandra P BelaniPenn State Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033, U.S.A.
Si-Yang ZhengDepartment of Biomedical Engineering, Micro & Nano Integrated Biosystem (MINIBio) Laboratory, The Pennsylvania State University, University Park, PA 16802, U.S.A.

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Integration of Flexible Micro Spring Array and High Throughput Microfluidics forDP2CA174508 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI ZHENG, SIYANG · 2012 to 2012
$2.2M
NCI NIH HHS DP2 CA174508NCI NIH HHS P30 CA016087
6 · The paper itself

Abstract

Extracellular vesicles (EVs) can mediate intercellular communication by transferring cargo proteins and nucleic acids between cells. The pathophysiological roles and clinical value of EVs are under intense investigation, yet most studies are limited by technical challenges in the isolation of nanoscale EVs (nEVs). Here, we report a lipid nanoprobe that enables spontaneous labelling and magnetic enrichment of nEVs in 15 minutes, with isolation efficiency and cargo composition similar to what can be achieved by the much slower and bulkier method of ultracentrifugation. We also show that the lipid nanoprobes, which allow for downstream analyses of nucleic acids and proteins, enabled the identification of

Identifiers

PMID28966872
PMCPMC5618714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.