ArticleBiomedical optics express2017
Fast varifocal two-photon microendoscope for imaging neuronal activity in the deep brain.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- MEMS Varifocal Optical Elements for Focus Control.Micromachines · 2025Review
- Multiphoton imaging of hippocampal neural circuits: techniques and biological insights into region-, cell-type-, and pathway-specific functions.Neurophotonics · 2024Review
- Technologies for depth scanning in miniature optical imaging systems [Invited].Biomedical optics express · 2023Review
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- Varifocal MEMS mirrors for high-speed axial focus scanning: a review.Microsystems & nanoengineering · 2023Review
- Dual-wavelength multimodal multiphoton microscope with SMA-based depth scanning.Biomedical optics express · 2022Article
- Multiphoton excitation imaging via an actively mode-locked tunable fiber-cavity SOA laser around 800 nm.Biomedical optics express · 2022Article
- Direct measurement of neuronal ensemble activity using photoacoustic imaging in the stimulated Fos-LacZ transgenic rat brain: A proof-of-principle study.Photoacoustics · 2021Article
- Temporal focusing multiphoton microscopy with optimized parallel multiline scanning for fast biotissue imaging.Journal of biomedical optics · 2021Article
- Dual GRIN lens two-photon endoscopy for high-speed volumetric and deep brain imaging.Biomedical optics express · 2021Article
- Calcium imaging in freely-moving mice during electrical stimulation of deep brain structures.Journal of neural engineering · 2020Article
- Multiphoton intravital microscopy in small animals: motion artefact challenges and technical solutions.Journal of microscopy · 2020Review
- Continuous focal translation enhances rate of point-scan volumetric microscopy.Optics express · 2019Article
- Five-dimensional two-photon volumetric microscopy of in-vivo dynamic activities using liquid lens remote focusing.Biomedical optics express · 2019Article
- Wide and Deep Imaging of Neuronal Activities by a Wearable NeuroImager Reveals Premotor Activity in the Whole Motor Cortex.Scientific reports · 2019Article
- Multiplexed temporally focused light shaping through a gradient index lens for precise in-depth optogenetic photostimulation.Scientific reports · 2019Article
- Imaging the aged brain: pertinence and methods.Quantitative imaging in medicine and surgery · 2019Review
- Leveraging calcium imaging to illuminate circuit dysfunction in addiction.Alcohol (Fayetteville, N.Y.) · 2019Review
- Dispersion compensation by a liquid lens (DisCoBALL).Applied optics · 2019Article
- Quasi-simultaneous multiplane calcium imaging of neuronal circuits.Biomedical optics express · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescence microendoscopy is becoming a promising approach for deep brain imaging, but the current technology for visualizing neurons on a single focal plane limits the experimental efficiency and the pursuit of three-dimensional functional neural circuit architectures. Here we present a novel fast varifocal two-photon microendoscope system equipped with a gradient refractive index (GRIN) lens and an electrically tunable lens (ETL). This microendoscope enables quasi-simultaneous imaging of the neuronal network activity of deep brain areas at multiple focal planes separated by 85-120 µm at a fast scan rate of 7.5-15 frames per second per plane, as demonstrated in calcium imaging of the mouse dorsal CA1 hippocampus and amygdala
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.