ArticleSleep science (Sao Paulo, Brazil)
Heart rate variability in restless legs syndrome and periodic limb movements of Sleep.
Article in Sleep science (Sao Paulo, Brazil). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04356794 (Heart Rate Variability Assessment in Dialysis Patients by Acupuncture), which is not on this map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Heart Rate Variability Assessment in Dialysis Patients by Acupuncture
Who cites it
9 citing papers in PubMed.
- Event duration, endotypes and hypoxic burden in obstructive sleep apnoea.ERJ open research · 2026Article
- Sympathetic Activation and Sleep-Related Movements: Integrating Autonomic, Dopaminergic, and Iron Deficiency Mechanisms.Brain sciences · 2026Review
- Machine learning-based prediction of restless legs syndrome using digital phenotypes from wearables and smartphone data.Scientific reports · 2025Article
- Time-Dependent Autonomic Dysregulation and Co-Activation Induced by Periodic Limb Movements in Sleep.Journal of clinical medicine · 2025Article
- Remote Monitoring of Sympathovagal Imbalance During Sleep and Its Implications in Cardiovascular Risk Assessment: A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Article
- The Validation of the SOMNOwatch™ Actigraphy System for Periodic Limb Movements in Sleep Assessment.Clocks & sleep · 2024Article
- Periodic Limb Movements Syndrome in Patients With Cerebral Small Vessel Disease: Protocol for a Prospective Observational Study.Frontiers in neurology · 2021Article
- Article
- Autonomic regulation during sleep and wakefulness: a review with implications for defining the pathophysiology of neurological disorders.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe relationship between the autonomic nervous system and restless legs syndrome (RLS) and periodic limb movements of sleep (PLMS) consists of varied and somewhat conflicting reports. In order to further elucidate these complexities, a retrospective analysis of polysomnography (PSG) records and clinical data was performed.
methodsRecords from 233 adult subjects were randomly selected and organized into one of four groups ("non-RLS/PLMS" [n=61], "RLS" [n=60], "PLMS" [n=58], and "RLS/PLMS" [n=54]). Heart rate variability (HRV) analysis was based on 5-minute samples of 2-lead electrocardiogram data isolated from PSG recordings during wakefulness and NREM sleep, and included mean RR interval (labeled "NN") and standard deviation of the RR intervals (labeled "SDNN"), and HRV power, very low frequency (VLF), low frequency (LF), and high frequency (HF) spectral bands.
resultsA significant reduction in the VLF band in the PLMS group as compared to the non-RLS/PLMS group (542±674
conclusionsThe PLMS group exhibited reduced basal sympathetic activity in wakefulness, but basal sympathetic predominance during NREM sleep, distinguishing this group from the RLS and RLS/PLMS groups.
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