Evidence map›Paper›PMID 28966659›Full record

ArticleResearch in autism spectrum disorders2017

Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder.

Rebecca A Lundwall, Kevin G Stephenson, E Shannon Neeley-Tass, Jonathan C Cox, Mikle South, Erin D Bigler, Emily Anderberg, Molly D Prigge, Blake D Hansen, Janet E Lainhart and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research in autism spectrum disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Evidence for Brainstem Contributions to Autism Spectrum Disorders.Frontiers in integrative neuroscience · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rebecca A LundwallBrigham Young University, Provo, UT 84602, USA.
Kevin G StephensonBrigham Young University, Provo, UT 84602, USA.
E Shannon Neeley-TassBrigham Young University, Provo, UT 84602, USA.
Jonathan C CoxBrigham Young University, Provo, UT 84602, USA.
Mikle SouthBrigham Young University, Provo, UT 84602, USA.
Erin D BiglerBrigham Young University, Provo, UT 84602, USA.
Emily AnderbergBrigham Young University, Provo, UT 84602, USA.
Molly D PriggeUniversity of Utah, 201 Presidents Circle, SLC, UT 84112, USA.
Blake D HansenUniversity of Utah, 201 Presidents Circle, SLC, UT 84112, USA.
Janet E LainhartUniversity of Wisconsin-Madison, 500 Lincoln Drive, Madison, WI 53706, USA.
Ryan O KellemsUniversity of Wisconsin-Madison, 500 Lincoln Drive, Madison, WI 53706, USA.
Jo Ann PetrieUniversity of Wisconsin-Madison, 500 Lincoln Drive, Madison, WI 53706, USA.
Terisa P GabrielsenUniversity of Wisconsin-Madison, 500 Lincoln Drive, Madison, WI 53706, USA.

Funding

Atypical Late Neurodevelopment in Autism: A Longitudinal MRI and DTI StudyR01MH080826 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI LAINHART, JANET ELIZABETH · 2007 to 2020
$6.5M
NIMH NIH HHS R01 MH080826
6 · The paper itself

Abstract

backgroundAggressive behaviors are common in individuals diagnosed with autism spectrum disorder (ASD) and may be phenotypic indicators of different subtypes within ASD. In current research literature for non-ASD samples, aggression has been linked to several brain structures associated with emotion and behavioral control. However, few if any studies exist investigating brain volume differences in individuals with ASD who have comorbid aggression as indicated by standardized diagnostic and behavioral measures.

methodWe examined neuroimaging data from individuals rigorously diagnosed with ASD versus typically developing (TD) controls. We began with data from brain volume regions of interest (ROI) taken from previous literature on aggression including the brainstem, amygdala, orbitofrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex. We defined aggression status using the Irritability subscale of the Aberrant Behavior Checklist and used lasso logistic regression to select among these predictor variables. Brainstem volume was the only variable shown to be a predictor of aggression status.

resultsWe found that smaller brainstem volumes are associated with higher odds of being in the high aggression group.

conclusionsUnderstanding brain differences in individuals with ASD who engage in aggressive behavior from those with ASD who do not can inform treatment approaches. Future research should investigate brainstem structure and function in ASD to identify possible mechanisms related to arousal and aggression.

Indexed as

aggressionAutismbrainstemimagingstructural MRI

Identifiers

PMID28966659
PMCPMC5617125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.